Protein Alignment CG2187 and Slc5a4a

DIOPT Version :10

• Sequence 1: NP_651890.1
• Gene: CG2187 / 43743
• FlyBaseID: FBgn0017448
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_573447.2
• Gene: Slc5a4a / 64452
• MGIID: 1927848
• Length: 656
• Species: Mus musculus
• Alignment Length: 693
• Identity: 153/693 - (22%)
• Similarity: 265/693 - (38%)
• Gaps: 192/693 - (27%)

  Fly     2 STTTTTTTTMASAVSSASQDLRFGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKM 66
            ||.:.:|:|.:|.:||.|.::. ...|..|.||.......:||: .....:::|...:...|:.|
Mouse     3 STASVSTSTASSELSSLSNNIN-NAADISVIVIYFVVVMAVGVW-AMLKTNRSTVGGFFLAGRSM 65

  Fly    67 QTLPIAISLVASQL--------------SGIAIMSIPAESYTYGFNYIFVVLAMLVVIPILIYII 117
            ...|:..||.||.:              ||||:.:..:.|:           |:|:|   |.:|.
Mouse    66 TWWPMGASLFASNIGSGHFVGLAGTGAASGIAVTAFESHSF-----------ALLLV---LGWIF 116

  Fly   118 VPVFYENNVSNCYEYLEMRFNKRTRQL---VTFFFVTNSFLMLPVYMFIPSLAFAQVTGMNIHLI 179
            ||::.:..|....|||:.||..:..|:   :.|.|:. ..|.:...:|..::......|:|::|.
Mouse   117 VPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFIC-VILTISADIFSGAIFIKLALGLNLYLA 180

  Fly   180 NVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVGVLGTIRSGGM---------------- 228
            .:::.:|...:|:.||:.:|::||.||..|||:....:.|...:..||.
Mouse   181 ILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESFTEKFMNAIPSVVE 245

  Fly   229 ---FTVMERASDGGRFNFDFGLDPRIRMTFWGATMGG-----IFMWTGHIGLNQSCVQRIVSLPS 285
               .|:..|.......:|....||......|..|..|     ::.|.    :||..|||.:...:
Mouse   246 GDNLTINSRCYTPQPDSFHIFRDPVTGDIPWPGTAFGMPITALWYWC----INQVIVQRCLCGKN 306

  Fly   286 YSHAKKSLIVSGLGFLIISFFNTISGIIMFARY-------------------YGCD----PMLAG 327
            .||.|.:.|:.|...|:..||..:.|:|....|                   .||.    |||.
Mouse   307 LSHVKAACILCGYLKLLPLFFMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAYPMLV- 370

  Fly   328 LVSKPDKMMPFFVQDIMGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFD-YIKPRIRHTEA 391
                 .|:||.          |:.|:.:|.:.::.:|||::..||.:.:...| |.|.|.:.:|.
Mouse   371 -----LKLMPM----------GLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTKIRKKASER 420

  Fly   392 RANWAMKLIVVVMGGYCIL---------GGFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVP 447
            ....|.:|.|.|:....||         ||.:|.    ..:.:.:..|   ..:..|||:.:|..
Mouse   421 ELLIAGRLFVSVLIVTSILWVPIVEVSQGGQLVH----YTEAISSYLG---PPIAAVFLVAVFCK 478

  Fly   448 RCNAKTAVTSIIVSVVAMVWIIANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTP 512
            |.|.:.|...::|.:|              .|||:                 ||||....|.
Mouse   479 RANEQGAFWGLMVGLV--------------MGLIR-----------------MIAEFSYGTG--- 509

  Fly   513 VTMKPPSGAPVTTAFHSDRDFSLYDISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQNPKLYSP 577
             :...||..|..          :..:.:.::.::   |.|:|.:.:..:
Mouse   510 -SCLAPSSCPKI----------ICGVHYLYFAII---LFFVCILVILGV---------------- 544

  Fly   578 FVRKFLSLPVTDQDLEEV--PLRGSKVAATPDLRIEPTEKEKQ 618
               .:|:.|:.|..|..:  .||.||     :.||:...::|:
Mouse   545 ---SYLTKPIPDVHLHRLCWALRNSK-----EERIDLDAEDKE 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_651890.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	134/607 (22%)
Slc5a4a	NP_573447.2	SLC5-6-like_sbd	27..656	CDD:444915	145/668 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	574..593		1/6 (17%)