Protein Alignment CG2187 and SLC5A7

DIOPT Version :10

• Sequence 1: NP_651890.1
• Gene: CG2187 / 43743
• FlyBaseID: FBgn0017448
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_068587.1
• Gene: SLC5A7 / 60482
• HGNCID: 14025
• Length: 580
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 117/636 - (18%)
• Similarity: 228/636 - (35%)
• Gaps: 194/636 - (30%)

  Fly    25 GLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEE----YLRGGKKMQTLPIAISLVASQLSGIAI 85
            ||....||.:::   ..:|::..:.:|:..:.||    .:.||:.:..|....::.|:.:.|..|
Human     7 GLIAIIVFYLLI---LLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYI 68

  Fly    86 MSIPAESYTYGFNYIFVVLAMLVVIPIL---IYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTF 147
            .......|..|:...:....:...:.::   ::...|:..:..|:....:.:: :.||...|
Human    69 NGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQI-YGKRMGGL--- 129

  Fly   148 FFVTNSFLMLPVYMFIPSL----------------AFAQVTGMNIHLINVMVSSICIFYTMLGGI 196
                         :|||:|                ..:.:..:::|:..::.:.|...||::||:
Human   130 -------------LFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGL 181

  Fly   197 KAVVWTDVVQGAIMLLSVVAVGV-----------------------------LGTIRSGGMFTVM 232
            .:|.:|||||     |..:.||:                             |||:.|..:::.:
Human   182 YSVAYTDVVQ-----LFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWL 241

  Fly   233 ERASDGGRFNFDFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIVSLPSYSHAKKSLIVSG 297
            :                    :|....:||| .|       |:..||::|..|.::|:....::.
Human   242 D--------------------SFLLLMLGGI-PW-------QAYFQRVLSSSSATYAQVLSFLAA 278

  Fly   298 LGFLIISFFNTISGIIMFA-----RYYGC-DPMLAGLVSKPDKMMPFFVQ---DIMGHLAGMPGV 353
            .|.|:::....:.|.|..:     ..||. ||.   ...:.|.::|..:|   .:.....|: |.
Human   279 FGCLVMAIPAILIGAIGASTDWNQTAYGLPDPK---TTEEADMILPIVLQYLCPVYISFFGL-GA 339

  Fly   354 FISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRHTEARANWAMKLIVVVMGGYCILGGFMVQNF 418
            ..:.|.|:|.||:.:..:..|..:|  .:..|...::....|.|::.|.|.|........:.:..
Human   340 VSAAVMSSADSSILSASSMFARNIY--QLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTV 402

  Fly   419 NSI---------------LQTVVTITGINT-GAVVGVFLLGMFV--------------------- 446
            ..:               |..|:.:.|.|| |||.| ::.|:|:
Human   403 YGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAG-YVSGLFLRITGGEPYLYLQPLIFYPGYY 466

  Fly   447 PRCNA--------KTA------VTSIIVSVVAMVWIIANGQMNFKSGLIKYEVLPNSLDQCEARG 497
            |..|.        ||.      :|:|.:|.:|        :..|:||     .||..||..:|..
Human   467 PDDNGIYNQKFPFKTLAMVTSFLTNICISYLA--------KYLFESG-----TLPPKLDVFDAVV 518

  Fly   498 LYMIAEAINKTDFTP---------VTMKPPSGAPVTTAFHSDRDFSLYDIS 539
            .....|.::||....         ..:||.....:::.|.:...|...|.|
Human   519 ARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEAFLDVDSS 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_651890.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	115/634 (18%)
SLC5A7	NP_068587.1	SLC5sbd_CHT	8..495	CDD:271368	97/546 (18%)
		Mediates interaction with SEC14L1. /evidence=ECO:0000250|UniProtKB:Q9JMD7	502..580		17/73 (23%)
		Dileucine-like motif. /evidence=ECO:0000269|PubMed:15953352	527..532		2/4 (50%)