DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2187 and slc5a5

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001082860.1	Gene:	slc5a5 / 561445	ZFINID:	ZDB-GENE-060503-585	Length:	601	Species:	Danio rerio

Alignment Length:	598	Identity:	187/598 - (31%)
Similarity:	305/598 - (51%)	Gaps:	39/598 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FGLTDYFVFVIMLGASAGIGVYFGF-FSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMS 87
            |.|.||.||..|||.|.|||::... .:..::..:.:..||:....:|:.:||.||.:|.:.::.
Zfish    11 FCLVDYAVFAAMLGVSVGIGLFQSLRKTPGRSKVDSFFTGGRGFSAVPVGLSLCASFMSAVQVLG 75

  Fly    88 IPAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTN 152
            :|:|:|.|||.::::.|...:...:...:.|||||...:::..:||.|||.:..:.|.:..|:..
Zfish    76 VPSETYLYGFKFLYMCLGQGLNSLMTAVLFVPVFYRLKITSSSQYLGMRFGRGMQLLGSLQFIVA 140

  Fly   153 SFLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAV 217
            :.|...:.:|.|::...|.||:|:.........||.|||.:||:|||:||||.|..:||...:||
Zfish   141 TLLYTGIVIFAPAVILNQATGLNMWASLFSTGLICTFYTTVGGMKAVIWTDVFQIVVMLSGFIAV 205

  Fly   218 GVLGTIRSGGMFTVMERASDGGRFNF-DFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIV 281
            .:.|||.:||...|:|.|::|.|.|| ||.:||:.|.:||..|:||..:|....|.||:.|||.:
Zfish   206 FIQGTILAGGPARVLEIANNGSRINFNDFAIDPQRRYSFWSFTVGGTMVWLSMYGANQAQVQRYI 270

  Fly   282 SLPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFVQDIMGH 346
            |..:...|:.:|:|:.:|..:|.......||:|||.|..|||:..|.:|.||:.||:.|.||..:
Zfish   271 SCRTEKQAQLALLVNQVGLCLIVSSAATCGIVMFALYSNCDPLKIGRISAPDQYMPYLVLDIFRN 335

  Fly   347 LAGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRHTEARANWAMKLIVVVMGGYCILG 411
            ..|.||:|::|.:|..||::|.::|::|.|...|.:||.:.....|....:...:.:..|   ||
Zfish   336 HPGFPGLFLACAYSGTLSTVSTSINAMAAVTMEDVMKPWLITISQRKQLMLSRALSLFYG---LG 397

  Fly   412 GFMVQNFNS-----ILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWIIAN 471
            ...:...:|     :||...|:.|:..|.::|.|.||||||..|.....:.:.|.....:|:...
Zfish   398 CITMAALSSLLDWGVLQGSFTVMGVVNGPLLGAFALGMFVPATNKPGVFSGVAVGFCLSLWLAVG 462

  Fly   472 GQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRDFSLY 536
            ..:...|..| ..|||.|..||      :...|...|..:.:.    |..|:..:|.     ::|
Zfish   463 STIYPPSPQI-MGVLPTSAGQC------LTTNATLNTTASVLA----SSVPLDYSFQ-----NIY 511

  Fly   537 DISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQNPKLYSPFVRKFLSLPVTDQDLEEVPLRGSK 601
            .||:.::..|.::.|.|..:.:|||..|.:.:..:|.|..             .:||:.|...|.
Zfish   512 SISYLYFGALSTSAVVLVGVVVSYITGPTKKDSISPGLLR-------------WNLEQKPCDASC 563

  Fly   602 VAATPDLRIEPTE 614
            ......:.:.|||
Zfish   564 HILNETITLNPTE 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	173/540 (32%)
slc5a5	NP_001082860.1	SLC5-6-like_sbd	14..549	CDD:320982	177/553 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580005
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950