DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2187 and slc5a8l

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001030141.1	Gene:	slc5a8l / 556156	ZFINID:	ZDB-GENE-061110-98	Length:	610	Species:	Danio rerio

Alignment Length:	614	Identity:	190/614 - (30%)
Similarity:	318/614 - (51%)	Gaps:	49/614 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMSI 88
            |.:.||.||..::..:||||::..|..:.:.:::|:|.||::|..:|:|:||.||.:|||.::..
Zfish    11 FSVWDYVVFAGLILVAAGIGLFQSFRGRKEASSDEFLLGGRQMTAVPVALSLTASFMSGITVIGT 75

  Fly    89 PAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTNS 153
            |||:|.||..:....::..::..|...|.||:||..|:::.|||||||:||..|.:.|..::..:
Zfish    76 PAEAYLYGTPFWLFFISYAIMSTISAEIFVPLFYRLNITSTYEYLEMRYNKLIRVIGTSMYIIQT 140

  Fly   154 FLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVG 218
            .|...:.:|.|:||..|:||:::..:.|...::||.|..|||:|||:||||.|..|||...|||.
Zfish   141 ALYTGMVIFAPALALNQITGLDLWGVLVATGAVCIIYCTLGGLKAVIWTDVFQMIIMLGGFVAVI 205

  Fly   219 VLGTIRSGGMFTVMERASDGGRF-NFDFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIVS 282
            ..|.:..||:..|...:..|||. .|.|..||..|.:||...:||..||.....:|||.|||.:|
Zfish   206 ARGAVLQGGLGRVWNDSFYGGRLETFSFDPDPLRRHSFWTIVVGGSLMWASMYSINQSQVQRYIS 270

  Fly   283 LPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFVQDIMGHL 347
            ..:.:|||.||.|:.:|..:......:||:.|::.|..|||.....|...|:::|:.|.||:...
Zfish   271 CRTMTHAKLSLYVNMVGLWVTVSLAMMSGLTMYSIYKDCDPFTNKDVGATDQLLPYLVMDILADF 335

  Fly   348 AGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRH-TEARANWAMKLIVVVMGGYCILG 411
            .|:||:|::..:|..||::|:::|:|..|...|::||.... ||.:.:|....:.|..|..||..
Zfish   336 PGLPGLFVAAAYSGTLSTVSSSINALVAVTVEDFMKPAWPSLTERQLSWINMGMSVFYGAVCIGM 400

  Fly   412 GFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWIIANGQMNF 476
            ..:.....:|||..::|.|:.:|.::|:::||||....|:...:..:...:...:|:....|:
Zfish   401 AGVASMMGNILQAALSIFGMISGPLLGLYMLGMFFRCANSTGGLAGLASGLAITLWVGIGAQL-- 463

  Fly   477 KSGLIKYEVLPN-------SLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFH-----S 529
                  |..||.       |::.|         .|:|.::.|  ||.|.|....||...     :
Zfish   464 ------YPPLPEKTLRLPLSVEGC---------VALNTSETT--TMTPFSTVLQTTTPQPRPALA 511

  Fly   530 DRDFSLYDISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQNPKLYSPFVRKFLSLPVTDQDLEE 594
            |   :.|.:|:.::..:|..:..:.|:.:|.|....:.:|..|:|:           ::..||
Zfish   512 D---NWYSLSYLYFSPVGIVVTMIIALIVSAISGGCKQKKVRPELF-----------ISKSDL-- 560

  Fly   595 VPLRGSKVAATPDLRIEPTEKEKQTVTEP 623
            :..|..|..:.....||...|:.|.:..|
Zfish   561 ICFRCKKSDSEVSDLIETKPKDNQGLDSP 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	176/547 (32%)
slc5a8l	NP_001030141.1	SLC5sbd_SMCT1	8..547	CDD:271402	178/557 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.940