DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2187 and CG6723

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_650069.2	Gene:	CG6723 / 41368	FlyBaseID:	FBgn0037895	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	596	Identity:	222/596 - (37%)
Similarity:	349/596 - (58%)	Gaps:	37/596 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RFGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMS 87
            ||...||..||.|.....|||:||||.:||. :.::|:.||:||..:|||.|||||.:|||.::.
  Fly    13 RFAWPDYVAFVSMFLLCIGIGIYFGFMNKSV-SEDDYMLGGRKMLVIPIAFSLVASFVSGITLLG 76

  Fly    88 IPAESYTYGFNYIFV---VLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFF 149
            :|.|.|:||..|::|   |:.|.||:.:   ..:|||::.|:::.|||||:||::|.|...:..|
  Fly    77 LPTEVYSYGIQYLYVSCGVIGMGVVMGV---FYLPVFHDLNITSTYEYLEVRFDRRLRLYGSVMF 138

  Fly   150 VTNSFLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSV 214
            ...:...||:.:::|:|||.||||:.:|.|..:|..||:|||.|||:||||||||||...||.::
  Fly   139 AIMNVAYLPIVIYVPALAFNQVTGIGVHTITPIVCIICVFYTSLGGLKAVVWTDVVQAISMLGAL 203

  Fly   215 VAVGVLGTIRSGGMFTVMERASDGGRFNF-DFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQ 278
            ..|.:.||...||...|:|||....|... |..:||.:|.|||....|||..||....::|:.:|
  Fly   204 CLVAIKGTRDIGGAGVVLERAWSSDRLEAPDLSIDPTVRHTFWCLFFGGIVYWTQTNAVSQNMIQ 268

  Fly   279 RIVSLPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFVQDI 343
            |.:||||...|:|:|.:..:|.||:......:|::::|.|..|||:...|....|:::|.||...
  Fly   269 RYLSLPSLGDARKALCIFCVGVLILMALCGYNGLLIYATYQNCDPLTTKLAKARDQLLPLFVMKT 333

  Fly   344 MGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRH--TEARANWAMKLIVVVMGG 406
            :|.|.||.|:||:.||||||||||..|||::.||..|::||.::.  :.:..||.|:|:||.:|.
  Fly   334 LGELPGMTGLFIAGVFSAALSSLSTCLNSMSAVVLEDFVKPYVKKPLSSSAINWIMRLVVVGVGV 398

  Fly   407 YCILGGFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWIIAN 471
            .|:...::|::..::||..:::..|..|.:.|:|.:|:|:|..|..:|:...::.|:||.|:..|
  Fly   399 LCVCLVYVVEHMGTVLQLTMSLEAITNGPLFGIFTIGLFLPWINGNSALVGGVMGVIAMSWVSLN 463

  Fly   472 GQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRD-FSL 535
            .|....||.|.|:..|.:::||:        .:.|.|         .|.|..|....|..| |.|
  Fly   464 AQWAIASGAITYKTKPLNVEQCD--------YSFNVT---------TSLANTTHLGASAEDIFPL 511

  Fly   536 YDISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQNPKLYSPFVRKFLSLPVTDQDLE----EVP 596
            |.||:.||...|:::....|:..::::..:...|.:|.|.:|.:|||.:.. :::.::    ::|
  Fly   512 YRISYMWYTTFGASITIFVALLGTFVFGKNNPNKVDPVLLTPCIRKFFAFG-SEKHMDAFRPDIP 575

  Fly   597 ----LRGSKVA 603
                ||..:||
  Fly   576 LQHKLRNDEVA 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	208/540 (39%)
CG6723	NP_650069.2	SLC5sbd_NIS-SMVT	17..537	CDD:271383	208/540 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448229
Domainoid	1	1.000	97	1.000	Domainoid score	I370
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900