Protein Alignment CG2187 and slc5a2

DIOPT Version :10

• Sequence 1: NP_651890.1
• Gene: CG2187 / 43743
• FlyBaseID: FBgn0017448
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_998091.1
• Gene: slc5a2 / 405862
• ZFINID: ZDB-GENE-040426-2498
• Length: 662
• Species: Danio rerio
• Alignment Length: 715
• Identity: 147/715 - (20%)
• Similarity: 252/715 - (35%)
• Gaps: 183/715 - (25%)

  Fly     1 MSTTTTTTTTMASAVSSASQDLRFGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKK 65
            |..||....|:.:|...:.      :..||:.||.:|       .:..|..::.|...|...|:.
Zfish     1 MENTTAKHVTINNAADISV------IIIYFLVVIAVG-------IWSTFRTNRGTVGGYFLAGRT 52

  Fly    66 MQTLPIAISLVASQL--------------SGIAIMSIPAESYTYGFNYIFVVLAMLVVIPILIYI 116
            |...|:..||.||.:              ||||:..       :.:|.:|:||       :|.::
Zfish    53 MVWWPVGTSLFASNIGSGHFVGLAGTAAASGIAVGG-------FEWNALFIVL-------LLGWV 103

  Fly   117 IVPVFYENNVSNCYEYLEMRFNKRTRQLV-----TFFFVTNSFLMLPVYMFIPSLAFAQVTGMNI 176
            .|||:....|....:||:.||......|.     .|.::   |..:.|.||..::...|..|.||
Zfish   104 FVPVYLTAGVITMPQYLKKRFGGSRISLYLSIISLFLYI---FTKISVDMFSGAVFIQQALGWNI 165

  Fly   177 HLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVGVLGTIRSGGMFTVMERASDG--- 238
            ::..:.:..|...||:.||:.|:::||.||..:::.....:........||...::|:.:..
Zfish   166 YVAVIALLCITALYTVTGGLAALMYTDTVQTFVIIAGAFVLMGFSFYEVGGYSALLEKYNSSLPS 230

  Fly   239 -------GRFN------------FDFGLDPRIRMTFW-----GATMGGIFMWTGHIGLNQSCVQR 279
                   ..:|            |....||......|     |..:.|.:.|.    .:|..|||
Zfish   231 QTLSLNPNEYNISQHCYMPREDAFHLLRDPTTGDLPWPGVIFGIAIIGSWYWC----TDQVIVQR 291

  Fly   280 IVSLPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYG---------CDPMLAGLVSKPDKM 335
            .::..|.:|.|...|:.|...|:..|.....|:|....|..         |:.:....|...:..
Zfish   292 CLAARSLTHVKAGCILCGYLKLLPMFLMVFPGMISRVLYPDDVGCVEKSVCNKVCGTEVGCSNIA 356

  Fly   336 MPFFVQDIMGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFDY---IKPRIRHTEARANWAM 397
            .|..|..:|.  .|:.|:.::.:.:|.:|||::..||.:.:...|.   |:|:.|..|......:
Zfish   357 YPKLVVSVMP--TGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIWTRIRPQARDKELMVVGRV 419

  Fly   398 KLIVVVMGGYCILGGFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSV 462
            .::.:|....|.:..........:...:.::|......:..||.|.:||.|.|...|
Zfish   420 WILCIVGISTCWIPVVQAAQSGQLFDYIQSVTSYLAPPIAAVFFLAIFVKRVNESGA-------- 476

  Fly   463 VAMVWIIANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAF 527
               .|.:..|.:   .||.:                 |:.|.:    |...:...||..|..
Zfish   477 ---FWGLMGGLV---MGLCR-----------------MVPEFV----FGSGSCLKPSNCPKV--- 511

  Fly   528 HSDRDFSLYDISFYWYKVLGSALVFLCAIPLSYIW--RPDENEKQNPKLYSPFVRKFLSLPVTDQ 590
                   :..:.:.::.:|   |.|..||.:.::.  .|...:|...:|.  |..:..:....|.
Zfish   512 -------ICGVHYLYFAIL---LFFCTAILVLFVSYNTPPIKDKHLHRLV--FTLRHSTEERVDL 564

  Fly   591 DLEEVPLRGSKVAATPD--------------------LRI-------------EPTEKEKQTVTE 622
            |.||.. ||.|.....|                    ::|             ||||:|   |||
Zfish   565 DWEEEE-RGRKARREADEKRRAKNDEDQIERGEQSIMMKIIGWFCGISDTQAPEPTEEE---VTE 625

  Fly   623  622
            Zfish   626  625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_651890.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	121/591 (20%)
slc5a2	NP_998091.1	SLC5sbd_SGLT2	15..662	CDD:212056	142/701 (20%)