DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2187 and slc5a12

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_956662.1	Gene:	slc5a12 / 393339	ZFINID:	ZDB-GENE-040426-1343	Length:	623	Species:	Danio rerio

Alignment Length:	586	Identity:	195/586 - (33%)
Similarity:	307/586 - (52%)	Gaps:	39/586 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RFGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMS 87
            ||...||.||..:...|:||||:|....::|..::|:|.||::|...|:|:||.||.:|.:.::.
Zfish     6 RFQAGDYVVFACLFVVSSGIGVFFAIKERNKAPSKEFLVGGRQMSCGPVALSLTASFMSAVTVIG 70

  Fly    88 IPAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTN 152
            .||:.|.:|.:|:...:|...|:.....:.:||||.:.:::.|||||:||.|..|...|..::..
Zfish    71 APADVYRFGASYVIFGVAYTFVVFFTAELFLPVFYRSGITSTYEYLELRFCKLVRVAATLIYIIQ 135

  Fly   153 SFLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAV 217
            :.|...|.::.|:||..||||.::.........:|.||..|||:|||||||..|..:|::..:.|
Zfish   136 TILYTGVVVYAPALALNQVTGFDLWGSIFATGIVCTFYCTLGGLKAVVWTDAFQMVVMVVGFLTV 200

  Fly   218 GVLGTIRSGGMFTVMERASDGGRFN-FDFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIV 281
            .:.|:.|:||:..|...:..|||.. |||.:.|..|.|||..::||.|.|.|..|:|||.:||.:
Zfish   201 LIQGSSRAGGIENVWSTSRTGGRLQVFDFDVSPLRRHTFWTLSVGGTFTWLGIYGVNQSTIQRCI 265

  Fly   282 SLPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFVQDIMGH 346
            |..:..||:.:|.::.||..||.|...:||:||::.|..|||..:||:|.||::||:||.:|:|.
Zfish   266 SCKTEGHARWALYLNLLGLWIILFCAVVSGLIMYSYYSHCDPWSSGLISAPDQLMPYFVMEILGA 330

  Fly   347 LAGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRHTEAR-ANWAMKLIVVVMGGYCIL 410
            ..|:||:|::|.||..||:::|::|:||.|:|.|::.........| |:|..|.:.|..|..|..
Zfish   331 FPGLPGLFVACAFSGTLSTVAASINALATVMYEDFVSQCFPDLSNRAASWISKALCVAFGVACTT 395

  Fly   411 GGFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWIIANGQMN 475
            ..........|:|..::|.|:..|.|:|:|.||:..|..|.|.||..:||.:....|:
Zfish   396 MAVAASYMGGIVQAALSIHGMCGGPVLGLFSLGILFPFTNLKGAVGGLIVGISLSFWV------- 453

  Fly   476 FKSGLIKYEVLPNSLDQCE--ARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRDF---SL 535
             ..|...|....|:....|  ..|..:.|.|...|..|            .|...|||::   |.
Zfish   454 -GVGAFIYPAPSNNTHALELNTAGCNITAAAFEPTSAT------------VTQLTSDRNWLADSW 505

  Fly   536 YDISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQNPKLYSPFVRK-------FLSLPVTDQDLE 593
            |.:|:.:|..:|........:.::.:..|     .:|||..|.:.:       |.:...|:.||.
Zfish   506 YSMSYLYYSAVGFIGTVAAGLLITLLTGP-----MDPKLLKPGMTRSVKEVMCFCTEKFTEADLG 565

  Fly   594 E 594
            |
Zfish   566 E 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	183/540 (34%)
slc5a12	NP_956662.1	SLC5sbd_SMCT2	4..533	CDD:212089	185/546 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580035
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950