DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2187 and CG5687

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	620	Identity:	178/620 - (28%)
Similarity:	316/620 - (50%)	Gaps:	62/620 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SSASQDLRFGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQL 80
            |:.|....|...||.:.:.||..|.|||:::|||.|..:::.|:|. |.:|...|:.:||..|.:
  Fly    88 SAPSHKATFSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLL-GSEMSIFPVTLSLTTSFI 151

  Fly    81 SGIAIMSIPAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLV 145
            :.|.::..|:|.|..|..::.:|:.|::|||:.:.|..|::::..:::|||||.:||.|..|.|.
  Fly   152 TAIELLGNPSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRFGKEIRILG 216

  Fly   146 TFFFVTNSFLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIM 210
            ...:|........|.:..|::|.::.||::..:..|::..:|:||:..||:||||..|..|.|::
  Fly   217 AVLYVIQMCFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIADSFQAAVL 281

  Fly   211 LLSVVAVGVLGTIRSGGMFTVMERASDGGR---FNFDFGLDPRIRMTFWGATMGGIFMWTGHIGL 272
            .:|:|.:..||...||....|.:.|||..|   ||.|  .||..|.|.|...:||.|.||.....
  Fly   282 AVSLVLIVGLGCFYSGNPIQVFQTASDHNRLEFFNMD--PDPTTRHTVWSVVIGGFFYWTSLFCT 344

  Fly   273 NQSCVQRIVSLPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMP 337
            ||:.||:.:||.|...||.:|..:.:|.:::...|..:|:::|..|..|||:.||.:|..|:::|
  Fly   345 NQASVQKCMSLKSLRLAKIALGFAIIGLIVVFLLNFYTGLMVFTHYADCDPLTAGRISATDQLLP 409

  Fly   338 FFVQDIMGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFDY--------IKPRIRHTEARAN 394
            ::|.:...|::.:.|:|::.:|:|:|.::::.||||:.|...|.        |.|....|.|:
  Fly   410 YYVINTYEHISSVAGIFVAGIFAASLGTVASALNSLSAVTCEDLLVNGMNIKISPEKGATYAK-- 472

  Fly   395 WAMKLIVVVMGGYCILG---GFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVT 456
            | |.|      |:.|..   .|:|::...:||..:|:.|:..|..:|:|:||:...:.|.|.|..
  Fly   473 W-MSL------GFGIASFGLVFIVEHLGGVLQATLTLNGLIGGVTLGLFVLGIACKQANTKGAFY 530

  Fly   457 SIIVSVVAMVWIIANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGA 521
            ..::|:..::::....|:    ..::...||.|:|:|:..        :|.|:.....:..|...
  Fly   531 GGLLSLALVIFVGVVAQI----VSVEQPALPTSIDKCDCH--------VNMTNIIGSLLTEPLEV 583

  Fly   522 PVTTAFHSDRDFSLYDISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQNPKLYSPFVRKFLSLP 586
            .....|.|   :.::.:|:.||.::|..|.......:|              |...|:::...|.
  Fly   584 IEEGGFTS---WPIFRLSYMWYSMIGCLLTVFLGWFIS--------------LIIDFIQRRNVLK 631

  Fly   587 VTDQDL------EEVPLRGSKVAATPDLRI-EPTE 614
            :|.:|:      ||:....|:|..|....| :|.|
  Fly   632 ITGKDIDNPAVSEEIFKSDSQVQYTTTTVIGDPRE 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	162/547 (30%)
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	162/561 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I370
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	9	8.970