DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2187 and CG10444

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_611465.2	Gene:	CG10444 / 37294	FlyBaseID:	FBgn0034494	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	581	Identity:	186/581 - (32%)
Similarity:	303/581 - (52%)	Gaps:	42/581 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMSI 88
            |...|..|.:.:|..||.||:|:.:....:.||:|||...:.|.|.|::.||:||.:|.|::|.:
  Fly     6 FDAWDAAVLITILVISALIGIYYRYTGGKQKTTQEYLMADQSMTTFPVSFSLMASFMSAISLMGV 70

  Fly    89 PAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTNS 153
            ..|||.:|..:..:.:|.::..||..|..:||||....::.|||||.||.:.||...:..|....
  Fly    71 SNESYEFGTIFCVINIAYVLSTPIAAYFFLPVFYRMRTTSVYEYLERRFGQATRLSASLAFTVQM 135

  Fly   154 FLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVG 218
            .|.:.:.::.|:||...|||::..:..|::..:|.||:.|||:|||:.|||.|..:|..::.||.
  Fly   136 VLYMGIALYAPALALEAVTGIHRSMAIVVIGLVCTFYSTLGGLKAVLITDVFQSFLMFAAIYAVI 200

  Fly   219 VLGTIRSGGMFTVMERASDGGRFNF-DFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIVS 282
            .:..|::||...:.:.|.:.||.|| :|.|||.:|.|:|...:||:..:....|:||:.|||::|
  Fly   201 AVSAIKAGGFAAIWDVAVERGRVNFIEFSLDPTVRHTWWSLIIGGMVTYLSLYGVNQTQVQRLLS 265

  Fly   283 LPSYSHAKKSL--IVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFVQDIMG 345
            :.:...|:.:|  .:..||.|  ||....||:.:|..|..|||:|.|.:.|.|::||.|..:.||
  Fly   266 VRNLKSAQSALWWNLPILGML--SFSTIFSGLSIFYYYRDCDPLLKGRIDKRDQIMPLFALETMG 328

  Fly   346 HLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRH------TEARANWAMKLIVVVM 404
            ...|:.|:|:|.:|||:||::|:.:.||:.|...||:||..:.      .::::....|::..:.
  Fly   329 QYPGLCGLFVSGIFSASLSTISSAVTSLSAVTLEDYLKPLYKAIFKRTLIDSKSTMPTKIVACIF 393

  Fly   405 GGYCILGGFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWII 469
            |..||...|:..:...:||..:||.|:..|.::.:|.||:...|.|.:..:...:||::...|
  Fly   394 GLLCIGLAFVAGSMGGVLQASLTIFGVVGGPLLAIFTLGVCTTRSNQRGVLLGFLVSLIVSFW-- 456

  Fly   470 ANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRDFS 534
                |.|.....|...|..|...|| ....::|.||..:       ...||..:...:     |.
  Fly   457 ----MGFGGPKPKPVTLEFSTAGCE-NATAVMARAIELS-------SKSSGVVIEPDY-----FW 504

  Fly   535 LYDISFYWYKVLGSALVFLCAIPLSY---IWRPDENEKQNPKLYSPFVRKFLSLPVTDQDL 592
            ||.||:.|..|:|    ||.|:.:.|   |......:.:|.::|....||.|     |.||
  Fly   505 LYRISYLWLSVIG----FLIAVVVGYFSSIVLAHCGKAENAEIYLDKSRKQL-----DYDL 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	176/545 (32%)
CG10444	NP_611465.2	SLC5sbd_NIS-SMVT	9..531	CDD:271383	176/546 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448241
Domainoid	1	1.000	97	1.000	Domainoid score	I370
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900