DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2187 and Slc5a12

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001102058.1	Gene:	Slc5a12 / 362188	RGDID:	1311652	Length:	619	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	179/561 - (31%)
Similarity:	295/561 - (52%)	Gaps:	22/561 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMSI 88
            |...||.||..:...|:||||:|....:.|.|:.|:|.||::|...|:|:||.||.:|.:.::..
  Rat     6 FEAWDYVVFAALFVISSGIGVFFAIKERKKTTSREFLVGGRQMSFAPVALSLTASFMSAVTVLGT 70

  Fly    89 PAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTNS 153
            |||.|.:|.:::..:::...|:.....:.:||||.:.:::.||||::||||..|...|..::..:
  Rat    71 PAEVYRFGASFLIFLISYAFVVFFTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATIIYILQT 135

  Fly   154 FLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVG 218
            .|...|.::.|:||..||||.|:.........:|.||..|||:|||||||..|..:|::..:.|.
  Rat   136 ILYTGVVVYAPALALNQVTGFNLWASVFATGIVCTFYCSLGGLKAVVWTDAFQMVVMIVGFLTVL 200

  Fly   219 VLGTIRSGGMFTVMERASDGGRFNF-DFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIVS 282
            :.|:...||...|:|:|.:|.|.:. ||.:||..|.|||...:||.|.|.|..|:|||.:||.:|
  Rat   201 IQGSNHVGGFDNVLEQARNGSRLDIVDFDVDPLRRHTFWTIAVGGTFTWLGIYGVNQSTIQRCIS 265

  Fly   283 LPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFVQDIMGHL 347
            ..:..|||.:|..:.||..||.......|:||:|.|..|||..:|.:..||::||:||.:|...:
  Rat   266 CKTEKHAKLALYFNLLGLWIIVVCAVFCGLIMYAYYKDCDPWTSGAILAPDQLMPYFVMEIFATM 330

  Fly   348 AGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRH-TEARANWAMKLIVVVMGGYCILG 411
            .|:||:|::|.||..||:::|::|:||.|.:.|::|....| ::..:.|..|.:.::.|..|...
  Rat   331 PGLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFPHLSDTLSTWISKGLCLLFGIICTSM 395

  Fly   412 GFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWIIANGQMNF 476
            ..:.....|::|..::|.|:..|.::|:|.||:..|..|.|.|:..::..:....| :..|...:
  Rat   396 AVLASLMGSVVQAALSIHGMCGGPMLGLFTLGLVFPFVNWKGALGGLLTGITLSFW-VGIGAFVY 459

  Fly   477 KSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRDFSLYDISFY 541
            .:...|...||.|.:.|..:         |||......:   |..||...       :.|.:|:.
  Rat   460 PAPDSKTLPLPLSTEFCVQQ---------NKTTTEAYQL---SSRPVLAD-------TWYSLSYL 505

  Fly   542 WYKVLGSALVFLCAIPLSYIWRPDENEKQNPKLYSPFVRKF 582
            ::..:|........|.:|::......:..:|.|..|....|
  Rat   506 YFSAVGCLGCIAAGIIISFLTGRQRGKDVDPLLIRPVCNLF 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	174/535 (33%)
Slc5a12	NP_001102058.1	SLC5sbd_SMCT2	3..527	CDD:212089	175/540 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340189
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850