DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2187 and Slc5a1

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_037165.1	Gene:	Slc5a1 / 25552	RGDID:	3713	Length:	665	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	134/532 - (25%)
Similarity:	218/532 - (40%)	Gaps:	88/532 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STTTTTTTTMASAVSSASQDLRFGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKM 66
            |:|.:...|...|...:.:.:| ...|..|.||.......:|:: ..||.::.|...:...|:.|
  Rat     3 SSTLSPAVTATDAPIQSYERIR-NAADISVIVIYFVVVMAVGLW-AMFSTNRGTVGGFFLAGRSM 65

  Fly    67 QTLPIAISLVASQLS-----GIAIMSIPAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNV 126
            ...||..||.||.:.     |:|.....|.....||.:     ..||.:.:|.::.||::.:..|
  Rat    66 VWWPIGASLFASNIGSGHFVGLAGTGAAAGIAMGGFEW-----NALVFVVVLGWLFVPIYIKAGV 125

  Fly   127 SNCYEYLEMRFNKRTRQLVTFFFVTNSFLMLPVYMFIPSLA-------FAQVT-GMNIHLINVMV 183
            ....|||..||..:..|:..      |.|.|.:|:|....|       |..:. |::|:|...::
  Rat   126 VTMPEYLRKRFGGKRIQIYL------SVLSLLLYIFTKISADIFSGAIFINLALGLDIYLAIFIL 184

  Fly   184 SSICIFYTMLGGIKAVVWTDVVQGAIMLL-SVVAVG------------------VLGTIRSGGMF 229
            .:|...||:.||:.||::||.:|.||||: |.:..|                  .:.|:.|.|..
  Rat   185 LAITALYTITGGLAAVIYTDTLQTAIMLVGSFILTGFAFREVGGYEAFMDKYMKAIPTLVSDGNI 249

  Fly   230 TVMERASDGGRFNFDFGLDPRIRMTFWGATMGGIFMWTGHI-GL----------NQSCVQRIVSL 283
            ||.|........:|....||          :.|...|.|.| ||          :|..|||.:|.
  Rat   250 TVKEECYTPRADSFHIFRDP----------ITGDMPWPGLIFGLSILALWYWCTDQVIVQRCLSA 304

  Fly   284 PSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDK-----------MMP 337
            .:.||.|....:.|...|:..|...:.|  |.:|....|.:...|.|:..|           ..|
  Rat   305 KNMSHVKAGCTLCGYLKLLPMFLMVMPG--MISRILYTDKIACVLPSECKKYCGTPVGCTNIAYP 367

  Fly   338 FFVQDIMGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFD-YIKPRIRHTEARANWAMKLIV 401
            ..|.::|.:  |:.|:.:|.:.::.:|||::..||.:.:...| |.|.|...:|.....|.:|.:
  Rat   368 TLVVELMPN--GLRGLMLSVMMASLMSSLTSIFNSASTLFTMDIYTKIRKGASEKELMIAGRLFI 430

  Fly   402 VVMGGYCILGGFMVQNFNS--ILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTA----VTSIIV 460
            :|:.|..|....:||:..|  :...:.:||......:..||||.:|..|.|...|    :...::
  Rat   431 LVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLILGFLI 495

  Fly   461 SVVAMVWIIANG 472
            .:..|:...|.|
  Rat   496 GISRMITEFAYG 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	129/507 (25%)
Slc5a1	NP_037165.1	SLC5-6-like_sbd	27..665	CDD:382020	129/507 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340177
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740