Protein Alignment CG2187 and Slc5a12

DIOPT Version :10

• Sequence 1: NP_651890.1
• Gene: CG2187 / 43743
• FlyBaseID: FBgn0017448
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_001003915.1
• Gene: Slc5a12 / 241612
• MGIID: 2138890
• Length: 623
• Species: Mus musculus
• Alignment Length: 583
• Identity: 183/583 - (31%)
• Similarity: 296/583 - (50%)
• Gaps: 62/583 - (10%)

  Fly    24 FGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMSI 88
            |...||.||..:...|:||||:|....:.|.|:.|:|.||::|...|:|:||.||.:|.:.::..
Mouse     6 FEAWDYVVFAGLFVISSGIGVFFAIKERKKTTSREFLVGGRQMSFGPVALSLTASFMSAVTVLGT 70

  Fly    89 PAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTNS 153
            |||.|.:|.::...:::.:.|:.....:.:||||.:.:::.||||::||||..|...|..::..:
Mouse    71 PAEVYRFGASFFLFLISYVFVVFFTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATIIYIVQT 135

  Fly   154 FLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVG 218
            .|...|.::.|:||..||||.|:.........:|.||..|||:|||||||..|..:|::..:.|.
Mouse   136 ILYTGVVVYAPALALNQVTGFNLWASVFATGIVCTFYCSLGGLKAVVWTDAFQMVVMIVGFLTVL 200

  Fly   219 VLGTIRSGGMFTVMERASDGGRFNF-DFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIVS 282
            :.|:...||...|:|:|.:|.|.:. ||.:||..|.|||..|:||.|.|.|..|:|||.:||.:|
Mouse   201 IQGSNHVGGFNNVLEKAGNGSRLHIVDFDVDPLRRHTFWTITIGGTFTWLGVYGVNQSTIQRCIS 265

  Fly   283 LPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFVQDIMGHL 347
            ..:..|||.:|..:.||..||......||:||::.:..|||..:|::|.||::||:||.:|...:
Mouse   266 CKTEKHAKLALYFNLLGLWIIVACAVFSGLIMYSHFKDCDPWTSGVISAPDQLMPYFVMEIFATM 330

  Fly   348 AGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRH-TEARANWAMKLIVVVMGGYCILG 411
            .|:||:|::|.||..||:::|::|:||.|.:.|::|....| ::..:.|..|       |.|||.
Mouse   331 PGLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFPHLSDKLSTWISK-------GLCILF 388

  Fly   412 GFMVQNF---NSILQTVVTITGI--NTGAVVGVF----------------LLGMFVPRCNAKTAV 455
            |.|..:.   .|::.:||...||  ...|:.|.|                ::|          |:
Mouse   389 GIMCTSMAVVASLMGSVVQAPGIVSQERAITGSFQRNLASVCYGVSIWKLIMG----------AL 443

  Fly   456 TSIIVSVVAMVWIIANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPP-S 519
            ..::..:....| :|.|...:.:...|...||.|.:.|         ..:|.|    .|:.|. |
Mouse   444 GGLLTGITLSFW-VAIGSFIYPAPESKTLPLPLSTEHC---------VELNIT----TTVAPQIS 494

  Fly   520 GAPVTTAFHSDRDFSLYDISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQNPKLYSPFVRKF 582
            ..||...       :.|.:|:.::..:|........|.:|::......:..:|.|..|....|
Mouse   495 SRPVLAD-------TWYSLSYLYFSAVGCLGCIAAGIIISFLTGKQRGKDIDPLLIRPVCNLF 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_651890.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	178/557 (32%)
Slc5a12	NP_001003915.1	SLC5-6-like_sbd	3..531	CDD:444915	179/562 (32%)