Protein Alignment CG2187 and Slc5a11

DIOPT Version :10

• Sequence 1: NP_651890.1
• Gene: CG2187 / 43743
• FlyBaseID: FBgn0017448
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_666310.1
• Gene: Slc5a11 / 233836
• MGIID: 1919316
• Length: 673
• Species: Mus musculus
• Alignment Length: 660
• Identity: 144/660 - (21%)
• Similarity: 262/660 - (39%)
• Gaps: 161/660 - (24%)

  Fly    29 YFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQL----------SGI 83
            ||:||:.:|..:.:       ...::|.:.|...|..|...|:..||.||.:          ||.
Mouse    35 YFLFVLAVGLWSTV-------RTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGA 92

  Fly    84 AI-MSIPAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRF--NKRTRQLV 145
            |: :|:.|    |..|.:|.||       :|.::.:|::....|:...|||..||  |:.:..|.
Mouse    93 AVGISVAA----YELNGLFSVL-------MLAWVFLPIYIAGQVTTMPEYLRRRFGGNRISITLA 146

  Fly   146 TFFFVTNSFLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIM 210
            ..:.....|..:.|.|:..::...|...::::|..|.:.:|...||:.||:.||::||.:|..||
Mouse   147 VLYLFIYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITALYTVAGGLAAVIYTDALQTVIM 211

  Fly   211 LL--------SVVAVGVLGTIRSGGMFTVMERASDGGRFNFDFGL----------DPRIRMTFW- 256
            |:        |..|||.:..::......:....|:    |...||          ||......|
Mouse   212 LIGAFILMGYSFAAVGGMEGLKDQYFLALASNRSE----NSSCGLPREDAFHIFRDPLTSDLPWP 272

  Fly   257 ----GATMGGIFMWTGHIGLNQSCVQRIVSLPSYSHAKKSLIVSGLGFLIISFFNTISGI---IM 314
                |.::..::.|.    .:|..|||.::..:.||||...:::....::..|.....|:   ::
Mouse   273 GILFGMSIPSLWYWC----TDQVIVQRSLAAKNLSHAKGGSLMAAYLKVLPLFLMVFPGMVSRVL 333

  Fly   315 FARYYGC-DPMLAGLV-SKP----DKMMPFFVQDIMGHLAGMPGVFISCVFSAALSSLSATLNSL 373
            |.....| .|.:...| |.|    |...|..|.:::.  .|:.|:.::.:.:|.:|||::..||.
Mouse   334 FPDQVACAHPDICQRVCSNPSGCSDIAYPKLVLELLP--TGLRGLMMAVMVAALMSSLTSIFNSA 396

  Fly   374 AGVVYFD---YIKPRIRHTEARA-----NWAMKLIVVV--------MGGYCILGGFMVQNFNSIL 422
            :.:...|   :|:||....|...     .:|:.|:.::        .||...:   .:|:.:|.|
Mouse   397 STIFTMDLWNHIRPRASERELMIVGRIFVFALVLVSILWIPIVQASQGGQLFI---YIQSISSYL 458

  Fly   423 QTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWIIANGQMNFKSGLIKYEVLP 487
            |..|.:          ||::|.|..|.|.|.|.:.:|:.::.              ||::..:
Mouse   459 QPPVAM----------VFIMGCFWKRTNEKGAFSGLILGLLL--------------GLVRLIL-- 497

  Fly   488 NSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRDFSLYDISFYWYKVLGSALVF 552
                                 ||  |..:|....|      .||...:.|:.:.::.::.|....
Mouse   498 ---------------------DF--VYAQPRCDQP------DDRPAVVKDVHYLYFSMILSFTTL 533

  Fly   553 LCAIPLSYIWRPDENEKQNPKLYSPFVRKFLSLPVTDQDL--EEVPL------RGSKVAATPDLR 609
            :..:.:|  |..:...|:.....:.|.|   ..||..:|.  .|.||      .|:..|....::
Mouse   534 ITVVTVS--WFTETPSKEMVSRLTWFTR---HEPVAQKDSAPPETPLSLTLSQNGTTEAPGTSIQ 593

  Fly   610 IEPTEKEKQT 619
            :| |.:|..|
Mouse   594 LE-TVQESTT 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_651890.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	128/592 (22%)
Slc5a11	NP_666310.1	SLC5-6-like_sbd	28..673	CDD:444915	144/660 (22%)