DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2187 and Slc5a9

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_663526.3	Gene:	Slc5a9 / 230612	MGIID:	2140201	Length:	685	Species:	Mus musculus

Alignment Length:	661	Identity:	151/661 - (22%)
Similarity:	251/661 - (37%)	Gaps:	154/661 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 YFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLS-----GIAIMSI 88
            |||||:.:|..:.|       ..|:.|...|...|:.|...||..||::|.:.     |:|....
Mouse    40 YFVFVLAVGIWSSI-------RASRGTVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGA 97

  Fly    89 PAESYTYGF--NYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVT 151
            .......||  |..|::||       |.:|.|||:....|....:||:.||..:..|      |.
Mouse    98 AGGLAVGGFEWNATFLLLA-------LGWIFVPVYIAAGVVTMPQYLKKRFGGQRIQ------VY 149

  Fly   152 NSFLMLPVYMFIP--------SLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGA 208
            .|.|.|.:|:|..        :|......|.|::|..|::..:...||:.||:.||::||.:|..
Mouse   150 MSVLSLILYIFTKISTDIFSGALFIQMALGWNLYLSTVILLVVTAVYTIAGGLTAVIYTDALQTV 214

  Fly   209 IMLLSVVAVGVLGTIRSG---GMFTVMERA---------------SDGGRFNFDFGLDPRIRMTF 255
            ||:...:.:..||....|   |:..:..:|               .|.    |....||
Mouse   215 IMVGGALVLMFLGFQEVGWYPGLQQLYRQAIPNTTVPNTTCHLPRPDA----FHMLRDP------ 269

  Fly   256 WGATMGGIFMWTGHI-GL----------NQSCVQRIVSLPSYSHAKKSLIVSGLGFLIISFFNTI 309
                :.|...|.|.| ||          :|..|||.::..:.||||...::.|...::..||..:
Mouse   270 ----VNGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLAAKNLSHAKGGSVLGGYLKILPMFFIVM 330

  Fly   310 SGIIMFARYYG---------CDPMLAGLVSKPDKMMPFFVQDIMGHLAGMPGVFISCVFSAALSS 365
            .|:|..|.|..         |..:....|...:...|..|..:|.  .|:.|:.|:.:.:|.:||
Mouse   331 PGMISRALYPDEVACVDPDICQRVCGARVGCSNIAYPKLVMALMP--VGLRGLMIAVIMAALMSS 393

  Fly   366 LSATLNSLAGVVYFDYIKPRIRH--TEARANWAMKLIVVVMGGYCILGGFMVQNFNS--ILQTVV 426
            |::..||.:.:...| :..|.|.  :|.......:|.||.:....||...::|:.||  :...:.
Mouse   394 LTSIFNSSSTLFAID-VWQRFRRQASEQELMVVGRLFVVFLVVISILWIPIIQSSNSGQLFDYIQ 457

  Fly   427 TITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWIIANGQMNFKSGLIKYEVLPNSLD 491
            :||......:..:|||.:|..|.|...|...::..:|.              |:::. :|..|..
Mouse   458 SITSYLAPPITALFLLAIFCKRVNEPGAFWGLMFGLVV--------------GILRM-ILEFSYS 507

  Fly   492 QCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRDFSLYDISFYWYKVLGSALVFLCAI 556
                      |.|..:.|..|..:|                    |..:.::.:|...|..:..:
Mouse   508 ----------APACGEMDRRPAVLK--------------------DFHYLYFALLLCGLTAIIIV 542

  Fly   557 PLSYIWRPDENEK--------QNPKLYSPFVRKFLSLPVTDQDLEEVP-LRGSKVAATPDLRIEP 612
            .:|:...|..::|        :|..:..  ::|..|:.|.:.:.:..| |.|..|...|    ..
Mouse   543 VISFFTEPIPDDKLARLTWWTRNCAVSD--LQKKTSVSVNNTEDDNSPGLAGRPVVEGP----AG 601

  Fly   613 TEKEKQTVTEP 623
            .|:|..|...|
Mouse   602 DEEEANTTQGP 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	136/588 (23%)
Slc5a9	NP_663526.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SLC5-6-like_sbd	45..685	CDD:382020	146/656 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..616		10/40 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836473
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740