Protein Alignment CG2187 and SLC5A9

DIOPT Version :10

• Sequence 1: NP_651890.1
• Gene: CG2187 / 43743
• FlyBaseID: FBgn0017448
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: XP_047304539.1
• Gene: SLC5A9 / 200010
• HGNCID: 22146
• Length: 745
• Species: Homo sapiens
• Alignment Length: 787
• Identity: 162/787 - (20%)
• Similarity: 264/787 - (33%)
• Gaps: 255/787 - (32%)

  Fly     3 TTTTTTTTMASAVSSASQDLRFGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQ 67
            |.|.....:.|.|...:.|:.. :..||||||.:|..:.|       ..|:.|...|...|:.|.
Human    19 TETAPHIALDSRVGLHAYDISV-VVIYFVFVIAVGIWSSI-------RASRGTIGGYFLAGRSMS 75

  Fly    68 TLPIAISL---------------------------------------------------VASQLS 81
            ..||..||                                                   |.||:|
Human    76 WWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNMRKSRSGGDRGIHPRSHGRTGVRSQVS 140

  Fly    82 GIAIMSIPAESY----------------TYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCY 130
            ..::...|...:                |:.|:.:.....:|:.   |.::.|||:....|....
Human   141 YFSVRGPPTAQHCLWVGSRPSVYIQDLDTFFFSPLSQATWLLLA---LGWVFVPVYIAAGVVTMP 202

  Fly   131 EYLEMRFNKRTRQLVTFFFVTNSFLMLPVYMFIP--------SLAFAQVTGMNIHLINVMVSSIC 187
            :||:.||..:..|      |..|.|.|.:|:|..        :|......|.|::|...::..:.
Human   203 QYLKKRFGGQRIQ------VYMSVLSLILYIFTKISTDIFSGALFIQMALGWNLYLSTGILLVVT 261

  Fly   188 IFYTMLGGIKAVVWTDVVQGAIMLLSVVAVGVLGTIRSGGMFTVMERASDGGRFNFDFGLDPRIR 252
            ..||:.||:.||::||.:|..||:...:.:..||             ..|.|.:.   ||:.|.|
Human   262 AVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLG-------------FQDVGWYP---GLEQRYR 310

  Fly   253 MTFWGAT--------------------MGGIFMWTGHI-GL----------NQSCVQRIVSLPSY 286
            ......|                    :.|...|.|.| ||          :|..|||.:|..|.
Human   311 QAIPNVTVPNTTCHLPRPDAFHILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSL 375

  Fly   287 SHAKKSLIVSGLGFLIISFFNTISGII---MFARYYGC-DP-----MLAGLVSKPDKMMPFFVQD 342
            ||||...::.|...::..||..:.|:|   :|....|| ||     :....|...:...|..|..
Human   376 SHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDEVGCVDPDVCQRICGARVGCSNIAYPKLVMA 440

  Fly   343 IMGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFD-YIKPRIRHTEARANWAMKLIVVVMGG 406
            :|.  .|:.|:.|:.:.:|.:|||::..||.:.:...| :.:.|.:.||.......::.||.:..
Human   441 LMP--VGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQELMVVGRVFVVFLVV 503

  Fly   407 YCILGGFMVQNFNS--ILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWII 469
            ..||...::|:.||  :...:..:|......:..:|||.:|..|.....|...::..:..
Human   504 ISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGV----- 563

  Fly   470 ANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRDFS 534
                     ||::. :|..|..          |.|..:.|..|..:|
Human   564 ---------GLLRM-ILEFSYP----------APACGEVDRRPAVLK------------------ 590

  Fly   535 LYDISFYWYKVLGSAL-------VFLCAIPLSYIWRPDEN----------------EKQ----NP 572
              |..:.::.:|...|       |.||..|:     |:|.                ||:    .|
Human   591 --DFHYLYFAILLCGLTAIVIVIVSLCTTPI-----PEEQLTRLTWWTRNCPLSELEKEAHESTP 648

  Fly   573 KLYSPFVRKFLSLPV---------TDQDLEEVPLRG---------SKVAATPDLRIEPTEK---- 615
            ::..   |.....|.         ..|:..|.|.|.         ..::.||:..:.|.||
Human   649 EISE---RPAGECPAGGGAAENSSLGQEQPEAPSRSWGKLLWSWFCGLSGTPEQALSPAEKAALE 710

  Fly   616 EKQTVTE 622
            :|.|..|
Human   711 QKLTSIE 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_651890.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	138/658 (21%)
SLC5A9	XP_047304539.1	SLC5sbd_SGLT4	37..745	CDD:271380	158/769 (21%)