DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2187 and SLC5A12

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_848593.2	Gene:	SLC5A12 / 159963	HGNCID:	28750	Length:	618	Species:	Homo sapiens

Alignment Length:	568	Identity:	187/568 - (32%)
Similarity:	307/568 - (54%)	Gaps:	36/568 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMSI 88
            |.:.||.||..:...|:||||:|....:.|.|:.|:|.||::|...|:.:||.||.:|.:.::..
Human     6 FAVWDYVVFAALFFISSGIGVFFAIKERKKATSREFLVGGRQMSFGPVGLSLTASFMSAVTVLGT 70

  Fly    89 PAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTNS 153
            |:|.|.:|.:::...:|.|.||.:...:.:||||.:.:::.||||::||||..|...|..::..:
Human    71 PSEVYRFGASFLVFFIAYLFVILLTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATVIYIVQT 135

  Fly   154 FLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVG 218
            .|...|.::.|:||..||||.::.........:|.||..|||:|||||||..|..:|::..:.|.
Human   136 ILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGFLTVL 200

  Fly   219 VLGTIRSGGMFTVMERASDGGRFN-FDFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIVS 282
            :.|:..:||...|:|::::|.|.: |||.:||..|.|||..|:||.|.|.|..|:|||.:||.:|
Human   201 IQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRHTFWTITVGGTFTWLGIYGVNQSTIQRCIS 265

  Fly   283 LPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFVQDIMGHL 347
            ..:..|||.:|..:.||..||......||:||::.:..|||..:|::|.||::||:||.:|...:
Human   266 CKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHFKDCDPWTSGIISAPDQLMPYFVMEIFATM 330

  Fly   348 AGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRH-TEARANWAMKLIVVVMGGYCILG 411
            .|:||:|::|.||..||::::::|:||.|.:.|::|....| ::..:.|..|       |.|:|.
Human   331 PGLPGLFVACAFSGTLSTVASSINALATVTFEDFVKSCFPHLSDKLSTWISK-------GLCLLF 388

  Fly   412 GFMVQN-------FNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWII 469
            |.|..:       ...::|..::|.|:..|.::|:|.||:..|..|.|.|:..::..:....| :
Human   389 GVMCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVFPFVNWKGALGGLLTGITLSFW-V 452

  Fly   470 ANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRDFS 534
            |.|...:.:...|...||.|.|||            .|::.|      .:|.||.::.....| :
Human   453 AIGAFIYPAPASKTWPLPLSTDQC------------IKSNVT------ATGPPVLSSRPGIAD-T 498

  Fly   535 LYDISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQNPKLYSPFVRKF 582
            .|.||:.:|..:|.....:..:.:|.|......|...|.|..|....|
Human   499 WYSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPLLIRPVCNLF 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	180/542 (33%)
SLC5A12	NP_848593.2	SLC5sbd_SMCT2	3..527	CDD:212089	182/547 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146420
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850