Protein Alignment CG2187 and SLC5A11

DIOPT Version :9

• Sequence 1: NP_001189331.1
• Gene: CG2187 / 43743
• FlyBaseID: FBgn0017448
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_001339171.1
• Gene: SLC5A11 / 115584
• HGNCID: 23091
• Length: 675
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 140/639 - (21%)
• Similarity: 253/639 - (39%)
• Gaps: 160/639 - (25%)

  Fly    29 YFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQL----------SGI 83
            ||:||:.:|..:.:       ...::|.:.|...|..|...|:..||.||.:          ||.
Human    35 YFLFVLAVGLWSTV-------KTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGA 92

  Fly    84 AI-MSIPAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLV-- 145
            |. :|:.|    |..|.:|.||       :|.:|.:|::....|:...|||..||......::
Human    93 ATGISVSA----YELNGLFSVL-------MLAWIFLPIYIAGQVTTMPEYLRKRFGGIRIPIILA 146

  Fly   146 ---TFFFVTNSFLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQG 207
               .|.::   |..:.|.|:..::...|...::::|..|.:.:|...||:.||:.||::||.:|.
Human   147 VLYLFIYI---FTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQT 208

  Fly   208 AIMLLSVVAVGVLGTIRSGGMFTVMER-----ASDGGRFNFDFGL----------DPRIRMTFW- 256
            .|||:..:.:........|||..:.|:     ||:... |...||          ||......|
Human   209 LIMLIGALTLMGYSFAAVGGMEGLKEKYFLALASNRSE-NSSCGLPREDAFHIFRDPLTSDLPWP 272

  Fly   257 ----GATMGGIFMWTGHIGLNQSCVQRIVSLPSYSHAKKSLIVSG----LGFLIISFFNTISGII 313
                |.::..::.|.    .:|..|||.::..:.||||...:::.    |...|:.|...:|. |
Human   273 GVLFGMSIPSLWYWC----TDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIMVFPGMVSR-I 332

  Fly   314 MFARYYGC-DPMLA-GLVSKP----DKMMPFFVQDIMGHLAGMPGVFISCVFSAALSSLSATLNS 372
            :|.....| ||.:. .:.|.|    |...|..|.:::.  .|:.|:.::.:.:|.:|||::..||
Human   333 LFPDQVACADPEICQKICSNPSGCSDIAYPKLVLELLP--TGLRGLMMAVMVAALMSSLTSIFNS 395

  Fly   373 LAGVVYFD---YIKPRIRHTEARANWAMKLIVVVM-------------GGYCILGGFMVQNFNSI 421
            .:.:...|   :::||....|......:.::::|:             ||...:   .:|:.:|.
Human   396 ASTIFTMDLWNHLRPRASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFI---YIQSISSY 457

  Fly   422 LQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVWIIANGQMNFKSGLIKYEVL 486
            ||..|.:          ||::|.|..|.|.|.|...:|                  |||:
Human   458 LQPPVAV----------VFIMGCFWKRTNEKGAFWGLI------------------SGLL----- 489

  Fly   487 PNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAFHSDRDFSLYDISFYWYKVLGSALV 551
                     .||..:.     .||  :.::|....|      .:|...:..|.:.::.::.|.:.
Human   490 ---------LGLVRLV-----LDF--IYVQPRCDQP------DERPVLVKSIHYLYFSMILSTVT 532

  Fly   552 FLCAIPLSYIWRPDENEKQNP----KLYSPFVRKF-------LSLPVTDQDLEE 594
            .:....:|:...|...|..:.    ..:.|.|:|.       |||.::...:.|
Human   533 LITVSTVSWFTEPPSKEMVSHLTWFTRHDPVVQKEQAPPAAPLSLTLSQNGMPE 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	131/593 (22%)
SLC5A11	NP_001339171.1	SLC5sbd_SGLT6	28..675	CDD:271381	140/639 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840