DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2187 and Slc5a5

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_443215.2	Gene:	Slc5a5 / 114613	RGDID:	69267	Length:	618	Species:	Rattus norvegicus

Alignment Length:	603	Identity:	190/603 - (31%)
Similarity:	305/603 - (50%)	Gaps:	56/603 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMSI 88
            ||..||.||..||..|.|||::.|.....:.:.:::..||:::..:|:.:||.||.:|.:.::.:
  Rat    12 FGAWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVLGV 76

  Fly    89 PAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTNS 153
            |||:..||..::::....|:...:..::.:|:||...:::.|:|||:||::..|...|..::..:
  Rat    77 PAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVAT 141

  Fly   154 FLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVG 218
            .|...:.::.|:|...||||::|....:....||..||.:||:||||||||.|..:||:....:.
  Rat   142 MLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWVIL 206

  Fly   219 VLGTIRSGGMFTVMERASDGGRFN-FDFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIVS 282
            ..|.|..||...::..|.:..|.| .||..|||.|.|||...:||..:|....|:||:.|||.|:
  Rat   207 ARGVILLGGPRNMLSLAQNHSRINLMDFDPDPRSRYTFWTFIVGGTLVWLSMYGVNQAQVQRYVA 271

  Fly   283 LPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFVQDIMGHL 347
            ..:...||.:|:|:.||..:|.......||:||..|..|||:|.|.:|.||:.||..|.||...|
  Rat   272 CHTEGKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFEDL 336

  Fly   348 AGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRHTEARANWAMKLIVV------VMGG 406
            .|:||:|::|.:|..||:.|.::|::|.|...|.||||:.....|     ||:.:      :.|.
  Rat   337 PGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLAPR-----KLVFISKGLSFIYGS 396

  Fly   407 YC--------ILGGFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVV 463
            .|        :|||       .:||...|:.|:.:|.::|.|.|||.:|.||....::.:...:.
  Rat   397 ACLTVAALSSLLGG-------GVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLAAGLA 454

  Fly   464 AMVWIIANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPP------SGAP 522
            ..:| :|.|...:..|.....|||.|...|           .|.:    |.:.||      :|.|
  Rat   455 VSLW-VAVGATLYPPGEQTMGVLPTSAAGC-----------TNDS----VLLGPPGATNASNGIP 503

  Fly   523 VTTAFHSDRDF---SLYDISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQNP-KLYSPFVRKFL 583
             ::...:.|..   :.|.||:.:|..||:....||...:||:..|.:.....| .|:....|:..
  Rat   504 -SSGMDTGRPALADTFYAISYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQTA 567

  Fly   584 SL-PVTD-QDLEEVPLRG 599
            |: |..| ..|||..::|
  Rat   568 SVAPKEDTATLEESLVKG 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	176/557 (32%)
Slc5a5	NP_443215.2	SLC5sbd_NIS	15..549	CDD:271393	178/562 (32%)
Slc5a5	NP_443215.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340153
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.850