DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2187 and Slc5a5

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_444478.2	Gene:	Slc5a5 / 114479	MGIID:	2149330	Length:	618	Species:	Mus musculus

Alignment Length:	612	Identity:	196/612 - (32%)
Similarity:	312/612 - (50%)	Gaps:	45/612 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMSI 88
            ||..||.||..||..|.|||::.|.....:.:.:::..||:::..:|:.:||.||.:|.:.::.:
Mouse    12 FGPWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVLGV 76

  Fly    89 PAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTNS 153
            |||:..||..::::.:..|:...:...:.:|:||...:::.|:|||:||::..|...|..::..:
Mouse    77 PAEAARYGLKFLWMCVGQLLNSLLTALLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVAT 141

  Fly   154 FLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVG 218
            .|...:.::.|:|...||||::|....:....||..||.:||:||||||||.|..:||:....:.
Mouse   142 MLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWVIL 206

  Fly   219 VLGTIRSGGMFTVMERASDGGRFN-FDFGLDPRIRMTFWGATMGGIFMWTGHIGLNQSCVQRIVS 282
            ..|.:..||.:.|:..|.:..|.| .||..|||.|.|||...:||..:|....|:||:.|||.|:
Mouse   207 ARGVMLMGGPWNVLSLAQNHSRINLMDFDPDPRSRYTFWTFVVGGSLVWLSMYGVNQAQVQRYVA 271

  Fly   283 LPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYGCDPMLAGLVSKPDKMMPFFVQDIMGHL 347
            ..:...||.:|:|:.||..:|.......||:||..|..|||:|.|.::.||:.||..|.||...|
Mouse   272 CHTERKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRIAAPDQYMPLLVLDIFEDL 336

  Fly   348 AGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRHTEARANWAMKLIVV------VMGG 406
            .|:||:|::|.:|..||:.|.::|::|.|...|.||||:.....|     ||:.:      :.|.
Mouse   337 PGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPSLAPR-----KLVFISKGLSFIYGS 396

  Fly   407 YC--------ILGGFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVV 463
            .|        :|||       .:||...|:.|:.:|.::|.|.|||.:|.||....::.:...:.
Mouse   397 TCLTVAALSSLLGG-------GVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLTAGLA 454

  Fly   464 AMVWIIANGQMNFKSGLIKYEVLPNSLDQC-EARGLYMIAEAINKTDFTPVTMKPPSGAPVTTAF 527
            ..:| :|.|...:..|.....|||.|...| .|..|.....|.|.:...| :....||.|   ||
Mouse   455 VSLW-VAVGATLYPPGEQTMGVLPTSAAGCTNASVLPSPPGAANTSRGIP-SSGMDSGRP---AF 514

  Fly   528 HSDRDFSLYDISFYWYKVLGSALVFLCAIPLSYIWRPDENEKQNP-KLYSPFVRKFLSL-PVTD- 589
            ..    :.|.:|:.:|..||:....||...:||:..|.:.....| .|:....|:..|: |..|
Mouse   515 AD----TFYAVSYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQTASVAPKEDT 575

  Fly   590 QDLEEVPLRGSK--VAAT---PDLRIE 611
            ..||:..::|.:  .|||   |..|.|
Mouse   576 TTLEDSLVKGPEDIPAATKKPPGFRPE 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	177/549 (32%)
Slc5a5	NP_444478.2	SLC5sbd_NIS	15..549	CDD:271393	179/554 (32%)
Slc5a5	NP_444478.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	571..618		11/32 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836476
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5313
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.800