DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2187 and Slc5a10

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_006532041.1	Gene:	Slc5a10 / 109342	MGIID:	1926089	Length:	611	Species:	Mus musculus

Alignment Length:	497	Identity:	109/497 - (21%)
Similarity:	196/497 - (39%)	Gaps:	106/497 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RFGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMS 87
            :..:||..|..:....:..:|:: .....:|||...|...|:.|...||..||.||.......:.
Mouse    50 QLSVTDIIVISVYFALNVAVGIW-SACRANKNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFVG 113

  Fly    88 IPAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRF-NKRTRQLVTFFFVT 151
            :.......|                    :....:|.|:....||::.|| .:|.|   |:..|.
Mouse   114 LAGSGAAGG--------------------LAVAGFEWNIVTLPEYIQKRFGGQRIR---TYLSVL 155

  Fly   152 NSFLMLPVY------MFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIM 210
            :  |||.|:      ::..:|......|.|.:|..::..:|...||:.||:..|::||.:|..||
Mouse   156 S--LMLSVFTKISIDLYAGALFVHICLGWNFYLSTILTLAITALYTIAGGLATVIYTDALQTIIM 218

  Fly   211 LLSVVAVGVLGTIRSGGMFTV-------------------MERASDGGRFNFDFGLDPRIRMTFW 256
            ::..|.:.|....:.||...:                   :.||.....|.     ||......|
Mouse   219 VVGAVILAVKAFNQIGGYEQLEAAYAQAIPSRTIPNTTCHLPRADAMHMFR-----DPSTGDLPW 278

  Fly   257 -GATMGGIFMWTGHIGLNQSCVQRIVSLPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYYG 320
             |.|.|...|.|.:...:|..|||.:|..:.:|||       .|.::.|:...:...:|
Mouse   279 TGMTFGLTIMATWYWCTDQVIVQRSLSARNLNHAK-------AGSILASYLKMLPMGLM------ 330

  Fly   321 CDPMLAGLVSK---PDKM----------------------MPFFVQDIMGHLAGMPGVFISCVFS 360
               ::.|::|:   ||.:                      .|..|.::|.  .|:.|:.|:.:.:
Mouse   331 ---IMPGMISRVLFPDDVGCVVPSECLRACGAEIGCSNIAYPKLVMELMP--IGLRGLMIAVMMA 390

  Fly   361 AALSSLSATLNSLAGVVYFDYIKPRIRHTEARANWAM--KLIVVVMGGYCILGGFMVQNFNS--I 421
            |.||||::..||.:.:...| |..::|.:.......:  :|::||:.|..:....::|..||  :
Mouse   391 ALLSSLTSIFNSSSTLFTMD-IWRQLRPSAGERELLLVGRLVIVVLIGVSVAWIPVLQGSNSGQL 454

  Fly   422 LQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVV 463
            ...:.::|......|..:|:||:|..|.|.:.|...::..:|
Mouse   455 FIYMQSVTSSLAPPVTAIFILGIFWRRANEQGAFWGLMAGLV 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	109/493 (22%)
Slc5a10	XP_006532041.1	SLC5-6-like_sbd	52..611	CDD:382020	109/495 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836494
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740