Protein Alignment salt and SLC5A6

DIOPT Version :10

• Sequence 1: NP_651889.3
• Gene: salt / 43742
• FlyBaseID: FBgn0039872
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_066918.2
• Gene: SLC5A6 / 8884
• HGNCID: 11041
• Length: 635
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 189/594 - (31%)
• Similarity: 296/594 - (49%)
• Gaps: 39/594 - (6%)

  Fly    11 TVATATTATLEDLH--------FSLTDYIVFSLMLSASAGIGVYFGFFSKAKNTTEEYLQGGKRM 67
            :|..:|:|.|....        ||:.||:||.|:|..|..||:|.......::|..|.|...::|
Human     2 SVGVSTSAPLSPTSGTSVGMSTFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGELLMADRKM 66

  Fly    68 PTLPVAISLVSSQLSGVAMMSVPAETYSFGFNMIFVVWAMVLSVPVLIYIIVPVFYDNNVSNCYE 132
            ..||||:||:::..|.||::.||:|.|.||....|:.....|.:.:..:|.:||||..::::.||
Human    67 GCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYE 131

  Fly   133 YLELRFSKRTRQLVTITFILNQFLMLPVYMFVPSLAFSQVTGYNIHLINTVVSSICVFYTMLGGI 197
            ||||||:|..|...|:|||....:.:.|.::.||||.:.|||:::.|....:..:|..||.|||:
Human   132 YLELRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGL 196

  Fly   198 KAVVWTDVVQGSVMLISVVLVAILGTSNTGGITNVLENAAEGGRFD-FSFGIDPRLRLTFISGMA 261
            |||:||||.|..||.:..:.|.|:|::..||:..|...|::.||.. |....||.:|.||.:...
Human   197 KAVIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAF 261

  Fly   262 SGLLMWTGKLGLDQSCVQRIVSLPSYGHAKRCLLMAGVGF---LLIMSFTCFTGIIMFAYY--YG 321
            .|:.|.....|::|:.|||.:|..:   .|..:|.....|   .:.:...|..|::|||||  |.
Human   262 GGVFMMLSLYGVNQAQVQRYLSSRT---EKAAVLSCYAVFPFQQVSLCVGCLIGLVMFAYYQEYP 323

  Fly   322 CDPIQAGLVSKPDKLMPFFIQDIMGHMMGMPGVFISCVFSASLSSLSASLNSFAGVVYFDYIKPR 386
            ....||  .:.||:.:.:|:.|::..:.|:||:||:|:||.|||::|::.||.|.|...|.|:|.
Human   324 MSIQQA--QAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPW 386

  Fly   387 I-NHSEAKANATMKLVIVVMGAYCIVGGFIVQNFNSIIQTMWTITGINMGAVVGVFCLGMFVPRC 450
            . ..|||:|....:.:....|..|:...:|......::|...:|.|:..|.::|:||||||.|..
Human   387 FPEFSEARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCA 451

  Fly   451 NAKVAVSGIAFSCLVMLWIIINGQMNFKAGLIKYDPLPNGLDQCEAKGFEVILNAIRNKNVTNVG 515
            |...||.|:....::..||.|...:......:...| .||      ..|.:..|.    .|..|
Human   452 NPPGAVVGLLAGLVMAFWIGIGSIVTSMGSSMPPSP-SNG------SSFSLPTNL----TVATV- 504

  Fly   516 TTAIPSLEAPKELTTAFDSNRDFSIYDTSFYWYKVLGALLVFAWAIPMSYVWPLDKEEKQNPKLY 580
            ||.:|       |||..........|..|:.||....:..|....:.:|.:....:....||...
Human   505 TTLMP-------LTTFSKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATI 562

  Fly   581 SPFVRSMLN 589
            .|.:..:|:
Human   563 YPVLPKLLS 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
salt	NP_651889.3	SLC5sbd_NIS-SMVT	28..566	CDD:271383	179/544 (33%)
SLC5A6	NP_066918.2	SLC5sbd_SMVT	24..550	CDD:271394	181/549 (33%)