Protein Alignment salt and SLC5A4

DIOPT Version :10

• Sequence 1: NP_651889.3
• Gene: salt / 43742
• FlyBaseID: FBgn0039872
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: XP_016884409.1
• Gene: SLC5A4 / 6527
• HGNCID: 11039
• Length: 689
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 112/505 - (22%)
• Similarity: 200/505 - (39%)
• Gaps: 62/505 - (12%)

  Fly     4 SVSNLASTVATATTATLEDLHFSLTDYIVFSLMLSASAG-IGVYFGFFSKAKNTTEEYLQGGKRM 67
            |.|.|:..|..:.|.|..  |..|..: ..|.||..:.| ||   |||           ..|:.|
Human    48 SGSKLSVPVLLSETPTKR--HGPLASH-NHSAMLKTNRGTIG---GFF-----------LAGRDM 95

  Fly    68 PTLPVAISLVSSQLSGVAMMSVPAETYSFGFNMIFVVWAMVLSVPVLIYIIVPVFYDNNVSNCYE 132
            ...|:..||.:|.:.....:.:.....:.|...:...|...:.:.:|.:|.||::..:.|....|
Human    96 AWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPE 160

  Fly   133 YLELRFSKRTRQ--LVTITFILNQFLMLPVYMFVPSLAFSQVTGYNIHLINTVVSSICVFYTMLG 195
            ||:.||.....|  |..::..:...|::...:|..::......|.:::|...::.::...||..|
Human   161 YLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTG 225

  Fly   196 GIKAVVWTDVVQGSVMLISVVLVAILGTSNTGG-------ITNVLENAAEGGRFDFSFG-IDPRL 252
            |:.:|::||.:|..:|||...::.....:..||       ..|...:..||.....|.. ..||.
Human   226 GLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRA 290

  Fly   253 -RLTFISGMASGLLMWTGKL-GL----------DQSCVQRIVSLPSYGHAKRCLLMAGVGFLLIM 305
             .........:|.:.|.|.: |:          :|..|||.:......|.|...:|.....||.|
Human   291 DSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPM 355

  Fly   306 SFTCFTGIIMFAYYYGCDPIQAGLVSKPDK-----------LMPFFIQDIMGHMMGMPGVFISCV 359
            ......|:|....|  .|.:...:.|:..|           ..|..:.::|  ..|:.|:.:|.:
Human   356 FLMVMPGMISRILY--TDMVACVVPSECVKHCGVDVGCTNYAYPTMVLELM--PQGLRGLMLSVM 416

  Fly   360 FSASLSSLSASLNSFAGVVYFD-YIKPRINHSEAKANATMKLVIVVMGAYCIVGGFIVQ--NFNS 421
            .::.:|||::..||.:.:...| |.|.|...||.:.....::.::::....||...:||  ....
Human   417 LASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQ 481

  Fly   422 IIQTMWTITGINMGAVVGVFCLGMFVPRCNAKVA----VSGIAFSCLVML 467
            :|....:|:......:..||.|.:|..|.|.:.|    :.|:|...:.|:
Human   482 LIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMI 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
salt	NP_651889.3	SLC5sbd_NIS-SMVT	28..566	CDD:271383	104/481 (22%)
SLC5A4	XP_016884409.1	SLC5-6-like_sbd	76..689	CDD:444915	103/474 (22%)