Protein Alignment salt and SLC5A2

DIOPT Version :10

• Sequence 1: NP_651889.3
• Gene: salt / 43742
• FlyBaseID: FBgn0039872
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: XP_006721135.3
• Gene: SLC5A2 / 6524
• HGNCID: 11037
• Length: 698
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 124/544 - (22%)
• Similarity: 195/544 - (35%)
• Gaps: 157/544 - (28%)

  Fly    29 DYIVFSLMLSASAGIGVYFGFFSKAKNTTEEYLQGGKRMPTLPVAISLVSSQL------------ 81
            |.:|.:.......|:|:: ......:.|...|...|:.|...||..||.:|.:
Human    25 DILVIAAYFLLVIGVGLW-SMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTG 88

  Fly    82 --SGVAMMSVPAETYSFGFNMIFVVWAMVLSVPVLIYIIVPVFYDNNVSNCYEYLELRFSKRTRQ 144
              ||:|:.       .|.:|.:|||.       :|.::..||:....|....:||..||..|..:
Human    89 AASGLAVA-------GFEWNALFVVL-------LLGWLFAPVYLTAGVITMPQYLRKRFGGRRIR 139

  Fly   145 LV--TITFILNQFLMLPVYMFVPSLAFSQVTGYNIHLINTVVSSICVFYTMLGGIKAVVWTDVVQ 207
            |.  .::..|..|..:.|.||..::...|..|:||:.....:..|.:.||:.||:.|:::||.||
Human   140 LYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQ 204

  Fly   208 GSVMLISVVLVAILGTSNTGGIT-------------NVLENAAEGGRFDFSFGIDPR-------- 251
            ..|:|....::........||.:             .|.|:.|.|....|.:  .||
Human   205 TFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCY--RPRPDSYHLLR 267

  Fly   252 -------------LRLTFISGMASGLLMWTGKLGLDQSCVQRIVSLPSYGHAKRCLLMAGVGFLL 303
                         |.||.:||.     .|..    ||..|||.::..|..|.|...::.|...|.
Human   268 HPVTGDLPWPALLLGLTIVSGW-----YWCS----DQVIVQRCLAGKSLTHIKAGCILCGYLKLT 323

  Fly   304 IMSFTCFTGIIMFAYY-------------------YGCDPI-QAGLVSKPDKLMPFFIQDIMGHM 348
            .|......|:|....|                   .||..| ...||.   ||||
Human   324 PMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVV---KLMP---------- 375

  Fly   349 MGMPGVFISCVFSASLSSLSASLNSFAGVVYFDY---IKPRINHSEAKANATMKLVIVVMGAYCI 410
            .|:.|:.::.:.:|.:|||::..||.:.:...|.   ::||....|          ::::|...:
Human   376 NGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRE----------LLLVGRLWV 430

  Fly   411 VGGFIVQNFNSIIQTMW-----------------TITGINMGAVVGVFCLGMFVPRCNAKVAVSG 458
            |  |||     ::...|                 .::......|..||.|.:||||.|.:.|
Human   431 V--FIV-----VVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGA--- 485

  Fly   459 IAFSCLVMLWIIINGQMNFKAGLI 482
                    .|.:|.|.:...|.||
Human   486 --------FWGLIGGLLMGLARLI 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
salt	NP_651889.3	SLC5sbd_NIS-SMVT	28..566	CDD:271383	124/544 (23%)
SLC5A2	XP_006721135.3	SLC5sbd_SGLT2	24..698	CDD:212056	124/544 (23%)