Protein Alignment salt and Slc5a7

DIOPT Version :10

• Sequence 1: NP_651889.3
• Gene: salt / 43742
• FlyBaseID: FBgn0039872
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_071308.2
• Gene: Slc5a7 / 63993
• MGIID: 1927126
• Length: 580
• Species: Mus musculus
• Alignment Length: 677
• Identity: 133/677 - (19%)
• Similarity: 243/677 - (35%)
• Gaps: 190/677 - (28%)

  Fly    27 LTDYIVFSLMLSASAGIGVYFGFFSKAKNT------TEEYLQGGKRMPTLPVAISLVSSQLSGVA 85
            |...|:|.|::..   :|::..:  |.||:      :|..:.||:.:..|....::.::.:.|..
Mouse     8 LVAIILFYLLIFL---VGIWAAW--KTKNSGNPEERSEAIIVGGRDIGLLVGGFTMTATWVGGGY 67

  Fly    86 MMSVPAETYSFGFNMIFVVWAMVLSVPV---LIYIIVPVFYDNNVSNCYEYLELRFSKRTRQLVT 147
            :.......|..|..:   .||   ..|:   |..|:..:|               |:|..|....
Mouse    68 INGTAEAVYGPGCGL---AWA---QAPIGYSLSLILGGLF---------------FAKPMRSKGY 111

  Fly   148 ITFILNQFLMLPVY-------MFVPSL--------AFSQVTGYNIHL-------INTVVSS-ICV 189
            :| :|:.|..  :|       :|:|:|        |.....|..|.:       |:.:||: |.:
Mouse   112 VT-MLDPFQQ--IYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIVSALIAI 173

  Fly   190 FYTMLGGIKAVVWTDVVQGSVMLI----------------SVVLVAI--------LGTSNTGGIT 230
            .||::||:.:|.:|||||...:.|                .:...|:        |||..:..:.
Mouse   174 LYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIGFTAVHAKYQSPWLGTIESVEVY 238

  Fly   231 NVLENAAEGGRFDFSFGIDPRLRLTFISGMASGLLMWTGKLGLDQSCVQRIVSLPSYGHAKRCLL 295
            ..|:|                    |:..|..| :.|       |:..||::|..|..:|:....
Mouse   239 TWLDN--------------------FLLLMLGG-IPW-------QAYFQRVLSSSSATYAQVLSF 275

  Fly   296 MAGVGFLLIMSFTCFTGII-------MFAYYYGCDPIQAGLVSKPDKLMPFFIQ---DIMGHMMG 350
            :|..|.|::.......|.|       ..||.|. ||   ....:.|.::|..:|   .:.....|
Mouse   276 LAAFGCLVMALPAICIGAIGASTDWNQTAYGYP-DP---KTKEEADMILPIVLQYLCPVYISFFG 336

  Fly   351 MPGVFISCVFSASLSSLSASLNSFAGVVYFDYIKPRINHSEAKANATMKLVIVVMGAYCIVGGFI 415
            :..|..:.:.||..|.|||| :.||..:|  .:..|.|.|:.:....|::.::|.||.......:
Mouse   337 LGAVSAAVMSSADSSILSAS-SMFARNIY--QLSFRQNASDKEIVWVMRITVLVFGASATAMALL 398

  Fly   416 VQNFNSIIQTMWTITGINMGAVV--GVFCLGMFVPRCNAKVAVSGIAFSCLVMLWIIING----- 473
            .:.    :..:|.::...:..::  .:.|: :|:...|...||:|..|.    |::.|.|
Mouse   399 TKT----VYGLWYLSSDLVYIIIFPQLLCV-LFIKGTNTYGAVAGYIFG----LFLRITGGEPYL 454

  Fly   474 ---QMNFKAGLIKYDPLPNGL--DQCEAKGFEVILNAIRNKNVTNVGTTAIPSLEAPKELTTAFD 533
               .:.|..|   |....||:  .:...|...::.:...|..|:.:......|...|.:|
Mouse   455 YLQPLIFYPG---YYSDKNGIYNQRFPFKTLSMVTSFFTNICVSYLAKYLFESGTLPPKL----- 511

  Fly   534 SNRDFSIYDTSFYWYKVLGALLVFAWAIPMSYVWPLDKEEKQNPKLYSPFVRSMLNKPSPVLELE 598
                 .::|.                      |.....||..:..:........||:.:||...:
Mouse   512 -----DVFDA----------------------VVARHSEENMDKTILVRNENIKLNELAPVKPRQ 549

  Fly   599 ELPLKTPLSEEQ----IKEKENGSATE 621
            .|.|.:..:.::    :.....||.||
Mouse   550 SLTLSSTFTNKEALLDVDSSPEGSGTE 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
salt	NP_651889.3	SLC5sbd_NIS-SMVT	28..566	CDD:271383	119/615 (19%)
Slc5a7	NP_071308.2	SLC5sbd_CHT	8..495	CDD:271368	115/562 (20%)
		Mediates interaction with SEC14L1. /evidence=ECO:0000250|UniProtKB:Q9JMD7	502..580		17/107 (16%)
		Dileucine-like motif. /evidence=ECO:0000250|UniProtKB:Q9GZV3	527..532		0/4 (0%)