Protein Alignment salt and Slc5a2

DIOPT Version :10

• Sequence 1: NP_651889.3
• Gene: salt / 43742
• FlyBaseID: FBgn0039872
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_573517.1
• Gene: Slc5a2 / 246787
• MGIID: 2181411
• Length: 670
• Species: Mus musculus
• Alignment Length: 686
• Identity: 149/686 - (21%)
• Similarity: 244/686 - (35%)
• Gaps: 214/686 - (31%)

  Fly    29 DYIVFSLMLSASAGIGVYFGFFSKAKNTTEEYLQGGKRMPTLPVAISLVSSQL------------ 81
            |.:|.:.......|:|:: ..|...:.|...|...|:.|...||..||.:|.:
Mouse    23 DILVIAAYFLLVIGVGLW-SMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTG 86

  Fly    82 --SGVAMMSVPAETYSFGFNMIFVVWAMVLSVPVLIYIIVPVFYDNNVSNCYEYLELRF-SKRTR 143
              ||:|:.       .|.:|.:|||.       :|.::.|||:....|....:||..|| ..|.|
Mouse    87 AASGLAVA-------GFEWNALFVVL-------LLGWLFVPVYLTAGVITMPQYLRKRFGGHRIR 137

  Fly   144 -QLVTITFILNQFLMLPVYMFVPSLAFSQVTGYNIHLINTVVSSICVFYTMLGGIKAVVWTDVVQ 207
             .|..::..|..|..:.|.||..::...|..|:||:.....:..|.:.||:.||:.|:::||.||
Mouse   138 LYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQ 202

  Fly   208 GSVMLISVVLVAILGTSNTGGITNVLENAAEGGRFDFSFGIDPR--------------------- 251
            ..|:|....::........||.:.:.:... |.....:...||.
Mouse   203 TFVILAGAFILTGYAFHEVGGYSGLFDKYL-GAMTSLTVSKDPSVGNISSTCYQPRPDSYHLLRD 266

  Fly   252 ------------LRLTFISGMASGLLMWTGKLGLDQSCVQRIVSLPSYGHAKR-CLLMAGVGFLL 303
                        |.||.:||.     .|..    ||..|||.::..:..|.|. |:|   .|:|.
Mouse   267 PVTGDLPWPALLLGLTIVSGW-----YWCS----DQVIVQRCLAGKNLTHIKAGCIL---CGYLK 319

  Fly   304 IMSFTCFTGIIMFAYYYGCDPIQAGLVSK---PDK---LMPFFIQDIMGHMMG------------ 350
            :|.        ||..      :..|::|:   ||:   ::|...:.:.|..:|
Mouse   320 LMP--------MFLM------VMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVK 370

  Fly   351 -MP----GVFISCVFSASLSSLSASLNSFAGVVYFDY---IKPRINHSEAKANATMKLVIVVMGA 407
             ||    |:.::.:.:|.:|||::..||.:.:...|.   ::||....|......:.:|.:|  |
Mouse   371 LMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKELLLVGRLWVVFIV--A 433

  Fly   408 YCIVGGFIVQ--NFNSIIQTMWTITGINMGAVVGVFCLGMFVPRCNAKVAVSGIAFSCLVMLWII 470
            ..:....:||  ....:...:.:::......|..||.|.:||||.|.|.|           .|.:
Mouse   434 VSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGA-----------FWGL 487

  Fly   471 INGQMNFKAGLIKYDPLPN---GLDQCEAKGFEVILNAIRNKNVTNVGTTAIPSLEAPKELTTAF 532
            :.|.:...|.||     |.   |...|                   |..:|.|:|
Mouse   488 VGGLLMGLARLI-----PEFFFGSGSC-------------------VRPSACPAL---------- 518

  Fly   533 DSNRDFSIYDTSFYWY-----------KVLGALLVFAWAIPMSYVWPL------DKEEKQN---P 577
                    :....|.|           ..||..|..| .||..::..|      .|||:::   .
Mouse   519 --------FCRVHYLYFAIILFICSGILTLGISLCTA-PIPQKHLHRLVFSLRHSKEEREDLDAD 574

  Fly   578 KLYSPFVRSMLNKPSPV--------LELEELPLKTP 605
            :|..|       .|:||        :|:||:....|
Mouse   575 ELEGP-------APAPVQNGGQECAMEMEEVQSPAP 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
salt	NP_651889.3	SLC5sbd_NIS-SMVT	28..566	CDD:271383	136/628 (22%)
Slc5a2	NP_573517.1	SLC5-6-like_sbd	22..670	CDD:444915	149/686 (22%)