Protein Alignment salt and SLC5A11

DIOPT Version :10

• Sequence 1: NP_651889.3
• Gene: salt / 43742
• FlyBaseID: FBgn0039872
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001339171.1
• Gene: SLC5A11 / 115584
• HGNCID: 23091
• Length: 675
• Species: Homo sapiens
• Alignment Length: 663
• Identity: 150/663 - (22%)
• Similarity: 255/663 - (38%)
• Gaps: 189/663 - (28%)

  Fly    30 YIVFSLMLSASAGIGVYFGFFSKAKNTTEEYLQGGKRMPTLPVAISLVSSQL----------SGV 84
            |.:|.|      .:|::....:| ::|.:.|...|..|...||..||.:|.:          ||.
Human    35 YFLFVL------AVGLWSTVKTK-RDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGA 92

  Fly    85 AM-MSVPAETYSFGFNMIFVVWAMVLSVPVLIYIIVPVFYDNNVSNCYEYLELRFSK-RTRQLVT 147
            |. :||.|    :..|.:|       ||.:|.:|.:|::....|:...|||..||.. |...::.
Human    93 ATGISVSA----YELNGLF-------SVLMLAWIFLPIYIAGQVTTMPEYLRKRFGGIRIPIILA 146

  Fly   148 ITFI-LNQFLMLPVYMFVPSLAFSQVTGYNIHLINTVVSSICVFYTMLGGIKAVVWTDVVQGSVM 211
            :.:: :..|..:.|.|:..::...|....:::|....:.:|...||:.||:.||::||.:|..:|
Human   147 VLYLFIYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLIM 211

  Fly   212 LISVVLVAILGTSNTGGI------------TNVLENAAEGGRFDFSFGI--DPRLRLTFISGMAS 262
            ||..:.:.....:..||:            :|..||::.|...:.:|.|  ||          .:
Human   212 LIGALTLMGYSFAAVGGMEGLKEKYFLALASNRSENSSCGLPREDAFHIFRDP----------LT 266

  Fly   263 GLLMWTGKL-GL----------DQSCVQRIVSLPSYGHAKRCLLMAG---VGFLLIMSFTCFTGI 313
            ..|.|.|.| |:          ||..|||.::..:..|||...|||.   |..|.||.|......
Human   267 SDLPWPGVLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIMVFPGMVSR 331

  Fly   314 IMFAYYYGC-DP-IQAGLVSKP----DKLMPFFIQDIMGHMMGMPGVFISCVFSASLSSLSASLN 372
            |:|.....| || |...:.|.|    |...|..:.:::  ..|:.|:.::.:.:|.:|||::..|
Human   332 ILFPDQVACADPEICQKICSNPSGCSDIAYPKLVLELL--PTGLRGLMMAVMVAALMSSLTSIFN 394

  Fly   373 SFAGVVYFD---YIKPRINHSEAKANATMKLVIVVMGAYCIV-------GG--FI-VQNFNSIIQ 424
            |.:.:...|   :::||.:..|......:.::::|:.:...:       ||  || :|:.:|.:|
Human   395 SASTIFTMDLWNHLRPRASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQ 459

  Fly   425 TMWTITGINMGAVVGVFCLGMFVPRCNAKVAVSGIAFSCLVMLWIIINGQMNFKAGLIKY----- 484
            .          .|..||.:|.|..|.|.|.|           .|.:|:|.:   .||::.
Human   460 P----------PVAVVFIMGCFWKRTNEKGA-----------FWGLISGLL---LGLVRLVLDFI 500

  Fly   485 ---------DPLPNGLDQCEAKGFEVILNAIRNKNVTNVG-TTAIPSLEAPKELTTAFDSNRDFS 539
                     |..|..:.......|.:||:.:....|:.|. .|..||.|....||
Human   501 YVQPRCDQPDERPVLVKSIHYLYFSMILSTVTLITVSTVSWFTEPPSKEMVSHLT---------- 555

  Fly   540 IYDTSFYWYKVLGALLVFAWAIPMSYVWPLDKEEKQNPKLYSPFVRSMLNKPSPVLELEELPLKT 604
                   |:                                        .:..||::.|:.|...
Human   556 -------WF----------------------------------------TRHDPVVQKEQAPPAA 573

  Fly   605 PLSEEQIKEKENG 617
            |||   :...:||
Human   574 PLS---LTLSQNG 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
salt	NP_651889.3	SLC5sbd_NIS-SMVT	28..566	CDD:271383	141/610 (23%)
SLC5A11	NP_001339171.1	SLC5sbd_SGLT6	28..675	CDD:271381	150/663 (23%)