DRSC/TRiP Functional Genomics Resources

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Protein Alignment nero and Dohh

DIOPT Version :10

Sequence 1:NP_651887.1 Gene:nero / 43740 FlyBaseID:FBgn0261479 Length:302 Species:Drosophila melanogaster
Sequence 2:NP_598725.2 Gene:Dohh / 102115 MGIID:1915964 Length:302 Species:Mus musculus


Alignment Length:299 Identity:173/299 - (57%)
Similarity:226/299 - (75%) Gaps:2/299 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MVSQQQIEAIGGVLNNKERPLKERFRALFTLKNIGGGAAIEAISKAFDDDSALLKHELAYCLGQM 65
            ||::|:|||||..|.:.::||:.||||||||:.:||..||..||:.|:|.|||||||||||||||
Mouse     1 MVTEQEIEAIGKTLVDPKQPLQARFRALFTLRGLGGPDAISWISRGFEDSSALLKHELAYCLGQM 65

  Fly    66 QDAQALDILTKVLKDTTQEPMVRHEAAEAMGAIGHPDVLPILEEYKQDPVVEVAETCAIALDRVR 130
            :||:|:.:|..||:||:|||||||||.||:||||:|:||.:|::|..||||||||||.:|:.|:.
Mouse    66 RDARAIPVLADVLQDTSQEPMVRHEAGEALGAIGNPEVLGLLKQYSTDPVVEVAETCQLAVGRLE 130

  Fly   131 WLQSGQ-KVDDSNPYASVDPSPPTAGDKSVTELKAIYLDAQQSLFDRYRAMFSLRNLRTEESVLA 194
            |||... :...:.||.||||:|| |.::.|..|:...||..:.||:||||||:|||:..:|:.||
Mouse   131 WLQQHPGEATCAGPYLSVDPAPP-AAEQDVGRLREALLDEARPLFERYRAMFALRNVGGKEAALA 194

  Fly   195 IAEGLKDSSALFRHEVAFVLGQLQEPCSIPFLQENLEDRLENEMVRHECAEALGAIATEDCIQIL 259
            :||||:..||||||||.:||||||...::|.|...|....|:.||||||||||||||...|:..|
Mouse   195 LAEGLQCGSALFRHEVGYVLGQLQHEAAVPGLAATLARTTESPMVRHECAEALGAIARPACLAAL 259

  Fly   260 NRYAEDDKRVVKESCVIALDMCEYENSPEFQYADGLAKL 298
            ..:.||.::||:|||.:||||.|||:|.:|||||||.:|
Mouse   260 REHIEDPEQVVRESCEVALDMYEYESSQDFQYADGLERL 298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
neroNP_651887.1 HEAT <24..130 CDD:441023 71/105 (68%)
HEAT repeat 39..67 CDD:293787 21/27 (78%)
HEAT repeat 69..99 CDD:293787 19/29 (66%)
HEAT repeat 102..127 CDD:293787 15/24 (63%)
HEAT <176..278 CDD:441023 57/101 (56%)
HEAT repeat 223..252 CDD:293787 17/28 (61%)
HEAT repeat 254..280 CDD:293787 11/25 (44%)
DohhNP_598725.2 HEAT <24..129 CDD:441023 70/104 (67%)
HEAT repeat 39..67 CDD:293787 21/27 (78%)
HEAT-like PBS-type 1 54..80 18/25 (72%)
HEAT repeat 69..99 CDD:293787 19/29 (66%)
HEAT-like PBS-type 2 87..113 16/25 (64%)
HEAT 155..278 CDD:441023 63/122 (52%)
HEAT-like PBS-type 3 175..201 16/25 (64%)
HEAT-like PBS-type 4 206..232 14/25 (56%)
HEAT-like PBS-type 5 239..265 15/25 (60%)

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