DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha2 and TEF2

DIOPT Version :9

Sequence 1:	NP_524611.1	Gene:	eEF1alpha2 / 43736	FlyBaseID:	FBgn0000557	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_009676.1	Gene:	TEF2 / 852415	SGDID:	S000000322	Length:	458	Species:	Saccharomyces cerevisiae

Alignment Length:	461	Identity:	354/461 - (76%)
Similarity:	401/461 - (86%)	Gaps:	3/461 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKA 65
            |||||.|||:||||||||||||||||||||||||||||||||||||.|:||||||||||||||||
Yeast     1 MGKEKSHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKA 65

  Fly    66 ERERGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKN 130
            |||||||||||||||||.||.||:|||||||||||||||||||||||:||:|.|.|||||||||:
Yeast    66 ERERGITIDIALWKFETPKYQVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGVGEFEAGISKD 130

  Fly   131 GQTREHALLAFTLGVKQLIVGVNKMDSTEPPYSEARYEEIKKEVSSYIKKIGYNPASVAFVPISG 195
            |||||||||||||||:||||.||||||.:  :.|:|::||.||.|::|||:||||.:|.||||||
Yeast   131 GQTREHALLAFTLGVRQLIVAVNKMDSVK--WDESRFQEIVKETSNFIKKVGYNPKTVPFVPISG 193

  Fly   196 WHGDNMLEPSEKMPWFKGWSVERKEGKAEGKCLIDALDAILPPQRPTDKPLRLPLQDVYKIGGIG 260
            |:||||:|.:...||:|||..|.|.|..:||.|::|:|||..|.|||||||||||||||||||||
Yeast   194 WNGDNMIEATTNAPWYKGWEKETKAGVVKGKTLLEAIDAIEQPSRPTDKPLRLPLQDVYKIGGIG 258

  Fly   261 TVPVGRVETGLLKPGMVVNFAPVNLVTEVKSVEMHHEALTEAMPGDNVGFNVKNVSVKELRRGYV 325
            ||||||||||::||||||.|||..:.|||||||||||.|.:.:||||||||||||||||:|||.|
Yeast   259 TVPVGRVETGVIKPGMVVTFAPAGVTTEVKSVEMHHEQLEQGVPGDNVGFNVKNVSVKEIRRGNV 323

  Fly   326 AGDSKNNPPRGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFSEIKEKCDRRTGKTTETE 390
            .||:||:||:|.|.|.|.||||||||||:.||:||||||||||||:|.|:.||.|||:||..|..
Yeast   324 CGDAKNDPPKGCASFNATVIVLNHPGQISAGYSPVLDCHTAHIACRFDELLEKNDRRSGKKLEDH 388

  Fly   391 PKAIKSGDAAIIVLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVGVIKSVNFKETTSGKVTKAA 455
            ||.:||||||::..|||||:|||:|.|:|||||||||||||||||||||||: |...:.||||||
Yeast   389 PKFLKSGDAALVKFVPSKPMCVEAFSEYPPLGRFAVRDMRQTVAVGVIKSVD-KTEKAAKVTKAA 452

  Fly   456 EKAQKK 461
            :||.||
Yeast   453 QKAAKK 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha2	NP_524611.1	PTZ00141	1..450	CDD:185474	344/448 (77%)
TEF2	NP_009676.1	PTZ00141	1..443	CDD:185474	344/444 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343904
Domainoid	1	1.000	381	1.000	Domainoid score	I103
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	741	1.000	Inparanoid score	I76
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62187
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	1	1.000	-	-		otm46493
orthoMCL	1	0.900	-	-		OOG6_100227
Panther	1	1.100	-	-	LDO	PTHR23115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X149
TreeFam	1	0.960	-	-
	13	12.760