DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF1alpha2 and SUP35

DIOPT Version :9

Sequence 1:	NP_524611.1	Gene:	eEF1alpha2 / 43736	FlyBaseID:	FBgn0000557	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_010457.3	Gene:	SUP35 / 851752	SGDID:	S000002579	Length:	685	Species:	Saccharomyces cerevisiae

Alignment Length:	462	Identity:	167/462 - (36%)
Similarity:	261/462 - (56%)	Gaps:	40/462 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAE 66
            ||:  |::::.:||||:||||..|:|:|..|.:|||||||:|:||::.|:..:..:||:|..|.|
Yeast   257 GKD--HVSLIFMGHVDAGKSTMGGNLLYLTGSVDKRTIEKYEREAKDAGRQGWYLSWVMDTNKEE 319

  Fly    67 RERGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNG 131
            |..|.||::....|||.|...||:|||||:.::..||.|.||||..||:::|..||:|.|..:.|
Yeast   320 RNDGKTIEVGKAYFETEKRRYTILDAPGHKMYVSEMIGGASQADVGVLVISARKGEYETGFERGG 384

  Fly   132 QTREHALLAFTLGVKQLIVGVNKMDSTEPPYSEARYEEIKKEVSSYIKKIGYN-PASVAFVPISG 195
            |||||||||.|.||.:::|.|||||.....:|:.||::....||::::.|||| ...|.|:|:||
Yeast   385 QTREHALLAKTQGVNKMVVVVNKMDDPTVNWSKERYDQCVSNVSNFLRAIGYNIKTDVVFMPVSG 449

  Fly   196 WHGDNM---LEPSEKMPWFKGWSVERKEGKAEGKCLIDALDAILPPQRPTDKPLRLPLQDVYKIG 257
            :.|.|:   ::|.| .||:            .|..|::.||.:....|..:.|..||:  ..|:.
Yeast   450 YSGANLKDHVDPKE-CPWY------------TGPTLLEYLDTMNHVDRHINAPFMLPI--AAKMK 499

  Fly   258 GIGTVPVGRVETGLLKPGMVVNFAPVNLVTEVKSVEMHHEALTE---AMPGDNVGFNVKNVSVKE 319
            .:||:..|::|:|.:|.|......|.....|::::  ::|...|   ||.|:.|...:|.|..::
Yeast   500 DLGTIVEGKIESGHIKKGQSTLLMPNKTAVEIQNI--YNETENEVDMAMCGEQVKLRIKGVEEED 562

  Fly   320 LRRGYVAGDSKNNPPRGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFSEIKEKCDRRTG 384
            :..|:|. .|..||.:....|.||:.::.....||.|::.|:..|||.......::..|.::.|.
Yeast   563 ISPGFVL-TSPKNPIKSVTKFVAQIAIVELKSIIAAGFSCVMHVHTAIEEVHIVKLLHKLEKGTN 626

  Fly   385 KTTETEPKAIKSGDAAIIVLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVGVIKSVNFKETTSG 449
            :.::..|...|.|...|.||....|:|||::|::|.||||.:||...|:|:             |
Yeast   627 RKSKKPPAFAKKGMKVIAVLETEAPVCVETYQDYPQLGRFTLRDQGTTIAI-------------G 678

  Fly   450 KVTKAAE 456
            |:.|.||
Yeast   679 KIVKIAE 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha2	NP_524611.1	PTZ00141	1..450	CDD:185474	162/454 (36%)
SUP35	NP_010457.3	PRK10263	<30..>199	CDD:236669
SUP35	NP_010457.3	TEF1	254..685	CDD:227581	165/460 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X149
TreeFam	0	0.000	Not matched by this tool.
	3	2.810