DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha2 and si:dkey-37o8.1

DIOPT Version :9

Sequence 1:	NP_524611.1	Gene:	eEF1alpha2 / 43736	FlyBaseID:	FBgn0000557	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001157466.1	Gene:	si:dkey-37o8.1 / 407641	ZFINID:	ZDB-GENE-030131-5667	Length:	458	Species:	Danio rerio

Alignment Length:	460	Identity:	310/460 - (67%)
Similarity:	381/460 - (82%)	Gaps:	7/460 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKA 65
            |.||:||||:|:|||||.|||||||||:|||||||.|||||:||.|.:|||.|||||||||||||
Zfish     1 MAKERIHINLVIIGHVDGGKSTTTGHLVYKCGGIDHRTIEKYEKAATQMGKSSFKYAWVLDKLKA 65

  Fly    66 ERERGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKN 130
            ||||||||||:|.||.|.||..|||||||||||||||||||||||.|:|||:|..||||||||:|
Zfish    66 ERERGITIDISLLKFNTQKYTFTIIDAPGHRDFIKNMITGTSQADAALLIVSAAKGEFEAGISRN 130

  Fly   131 GQTREHALLAFTLGVKQLIVGVNKMDSTEPPYSEARYEEIKKEVSSYIKKIGYNPASVAFVPISG 195
            ||||||||||:|||||||:|.|||||.||||:|:.||:|:.:.||.::||||:...:|.|:||||
Zfish   131 GQTREHALLAYTLGVKQLVVCVNKMDLTEPPFSQKRYDEVVRNVSVFVKKIGFEIGAVPFIPISG 195

  Fly   196 WHGDNMLEPSEKMPWFKGWSVERKEGKAEGKCLIDALDAILPPQRPTDKPLRLPLQDVYKIGGIG 260
            |.|:||:.||:||.|||||.::||||...|:.|::.||::.||.|...|||||||||||||||:|
Zfish   196 WSGENMIVPSQKMQWFKGWKLKRKEGHCHGRTLLEVLDSLHPPVRNAGKPLRLPLQDVYKIGGVG 260

  Fly   261 TVPVGRVETGLLKPGMVVNFAPVNLVTEVKSVEMHHEALTEAMPGDNVGFNVKNVSVKELRRGYV 325
            |||||::|||:||||||:.|:|..|..||||:||||:.|..|:||.|||||:||||||.||||.|
Zfish   261 TVPVGKIETGVLKPGMVLTFSPAKLTAEVKSIEMHHQGLQTALPGHNVGFNIKNVSVKNLRRGDV 325

  Fly   326 AGDSKNNPPRGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFSEIKEKCDRRTGKTTETE 390
            ||:::.:||...:.|.||:|:|||||:|..||:|||||||.|::|:|:|::||.|||:|:..|:.
Zfish   326 AGNAQQDPPSDVSSFIAQIIMLNHPGKIKVGYSPVLDCHTTHVSCRFAELREKLDRRSGRKLESW 390

  Fly   391 PKAIKSGDAAIIVLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVGVIKSVNFKETTSGKVTKAA 455
            |:.::|||.|.:.|||:||||||||..:||||||||||::|||||||||||.       ||.:|.
Zfish   391 PQYLRSGDGATVKLVPNKPLCVESFFHYPPLGRFAVRDLKQTVAVGVIKSVE-------KVDQAK 448

  Fly   456 EKAQK 460
            :.:||
Zfish   449 KTSQK 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha2	NP_524611.1	PTZ00141	1..450	CDD:185474	305/448 (68%)
si:dkey-37o8.1	NP_001157466.1	PTZ00141	1..458	CDD:185474	310/460 (67%)
		EF1_alpha	9..239	CDD:206670	165/229 (72%)
		EF1_alpha_II	244..332	CDD:293894	63/87 (72%)
		EF1_alpha_III	337..438	CDD:294004	62/100 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62187
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100227
Panther	1	1.100	-	-	O	PTHR23115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X149
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.790