DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha2 and eEF2

DIOPT Version :9

Sequence 1:	NP_524611.1	Gene:	eEF1alpha2 / 43736	FlyBaseID:	FBgn0000557	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	126/561 - (22%)
Similarity:	194/561 - (34%)	Gaps:	197/561 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKA 65
            |.|::...|:.||.|||.||||.|..|:.|.|.|          ...:.|:..|     .|..|.
  Fly    13 MDKKRNIRNMSVIAHVDHGKSTLTDSLVSKAGII----------AGAKAGETRF-----TDTRKD 62

  Fly    66 ERERGITID---IALWKFETSK------------------YYVTIIDAPGHRDFIKNMITGTSQA 109
            |:||.|||.   |::: ||..:                  :.:.:||:|||.||...:.......
  Fly    63 EQERCITIKSTAISMY-FEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRVT 126

  Fly   110 DCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMD--------STEPPYS--E 164
            |.|:::|     :..:|:....:|.....:|..:   :.|:.:||||        ..|..|.  :
  Fly   127 DGALVVV-----DCVSGVCVQTETVLRQAIAERI---KPILFMNKMDRALLELQLDAEELYQTFQ 183

  Fly   165 ARYEEIKKEVSSY------IKKIGYNPA--SVAFVPISGWHG--------DNMLEPSEKMP---- 209
            ...|.:...:::|      :.::..:|:  ||.|.  ||.||        ..|.  |||..
  Fly   184 RIVENVNVIIATYNDDGGPMGEVRVDPSKGSVGFG--SGLHGWAFTLKQFSEMY--SEKFKIDVV 244

  Fly   210 ------W--------FKGWSVERKEGKAEGKC--LIDAL----DAILPPQRPTDKPLRLPLQDVY 254
                  |        .|.|..:::.......|  ::|.:    |||:.                |
  Fly   245 KLMNRLWGENFFNAKTKKWQKQKEADNKRSFCMYILDPIYKVFDAIMN----------------Y 293

  Fly   255 KIGGIGTV--PVG---------RVETGLLKPGM---------VVNFAPVNLVTEVKSVEMHHEAL 299
            |...|||:  .:|         :....|||..|         ::....::|.:.|.:.:...|.|
  Fly   294 KKEEIGTLLEKIGVTLKHEDKDKDGKALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRMEML 358

  Fly   300 TEAMPGDNVGFNVKNVSVKELRRGYVAGDSKNNPPRGAADFTAQVIVLNHPGQIANG-------- 356
            .|....|.....||:.........|:   ||..|......|.|...|.  .|::|.|
  Fly   359 YEGPHDDEAAIAVKSCDPDGPLMMYI---SKMVPTSDKGRFYAFGRVF--AGKVATGQKCRIMGP 418

  Fly   357 -YTPVLDCHTAHIACKFSEIKEKCDRRT----GKTTETEPKAIKSGDAAIIVLVPSKPLC----V 412
             |||          .|..::.||..:||    |:..|    ||:.        |||..:|    |
  Fly   419 NYTP----------GKKEDLYEKAIQRTILMMGRYVE----AIED--------VPSGNICGLVGV 461

  Fly   413 ESFQEFPPLGRFAVRDMRQTVAVGVIKSVNFKETTSGKVTK 453
            :.|                .|..|.|  ..||:..:.||.|
  Fly   462 DQF----------------LVKTGTI--TTFKDAHNMKVMK 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha2	NP_524611.1	PTZ00141	1..450	CDD:185474	123/556 (22%)
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	126/561 (22%)
		EF2	20..236	CDD:206672	59/243 (24%)
		EF2_snRNP_like_II	380..474	CDD:293901	31/138 (22%)
		EF2_snRNP_III	489..560	CDD:293918
		aeEF2_snRNP_like_IV	560..732	CDD:238839
		eEF2_snRNP_like_C	728..807	CDD:239763
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840