DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha2 and gspt1l

DIOPT Version :9

Sequence 1:	NP_524611.1	Gene:	eEF1alpha2 / 43736	FlyBaseID:	FBgn0000557	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_942101.1	Gene:	gspt1l / 325284	ZFINID:	ZDB-GENE-030131-4009	Length:	577	Species:	Danio rerio

Alignment Length:	444	Identity:	176/444 - (39%)
Similarity:	268/444 - (60%)	Gaps:	17/444 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERE 68
            :|.|:|:|.|||||:||||..|.::|..|.:||||:||:|:||:|..:.::..:|.||..:.||:
Zfish   149 KKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERD 213

  Fly    69 RGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQT 133
            :|.|:::....|||.|.:.||:|||||:.|:.|||.|.||||.|||:::|..||||.|..|.|||
Zfish   214 KGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQT 278

  Fly   134 REHALLAFTLGVKQLIVGVNKMDSTEPPYSEARYEEIKKEVSSYIKKIGYNP-ASVAFVPISGWH 197
            ||||:||.|.|||.|||.|||||.....:|..||||.|:::..::||:|:|| ..|.|:|.||.:
Zfish   279 REHAMLAKTAGVKHLIVLVNKMDDPTVNWSLERYEECKEKLVPFLKKVGFNPRKDVHFMPCSGLN 343

  Fly   198 GDNMLEPSEKMPWFKGWSVERKEGKAEGKCLIDALDAILPPQRPTDKPLRLPLQDVYKIGGIGTV 262
            |.|:.||:|..||:.|..            .|..||::....|.:|.|:|||:.|.||  .:|||
Zfish   344 GANLKEPAENCPWYTGLP------------FIPHLDSLPNFNRSSDGPVRLPIVDKYK--DMGTV 394

  Fly   263 PVGRVETGLLKPGMVVNFAPVNLVTEVKSVEMHHEALTEAMPGDNVGFNVKNVSVKELRRGYVAG 327
            .:|::|:|.:.....:...|.....||.|:........||.||:|:...:|.:..:|:..|::..
Zfish   395 ILGKLESGSIGKAQQLVMMPNRHTVEVLSLLSDEVETDEAGPGENLKLRLKGIEEEEILPGFILC 459

  Fly   328 DSKNNPPRGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFSEIKEKCDRRTGKTTETEPK 392
            :::|....|.. |.||::::.|...|..||..||..||.....:.:.:....|::||..::|.|:
Zfish   460 NAENLCHTGRT-FDAQIVIIEHKSIICPGYNAVLHIHTCIEEVQITALICLVDKKTGDKSKTRPR 523

  Fly   393 AIKSGDAAIIVLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVG-VIKSVNFKE 445
            .:|.....|..|..:..:|:|:|::||.:|||.:||..:|:|:| |:|.|..|:
Zfish   524 FVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVAEKD 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha2	NP_524611.1	PTZ00141	1..450	CDD:185474	176/444 (40%)
gspt1l	NP_942101.1	TEF1	150..572	CDD:227581	173/436 (40%)
		EF1_alpha	154..370	CDD:206670	109/227 (48%)
		eRF3_II	379..460	CDD:293906	25/82 (30%)
		eRF3_C_III	466..572	CDD:294003	34/106 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X149
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920