DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha2 and hbs1l

DIOPT Version :9

Sequence 1:	NP_524611.1	Gene:	eEF1alpha2 / 43736	FlyBaseID:	FBgn0000557	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001295477.1	Gene:	hbs1l / 324267	ZFINID:	ZDB-GENE-030131-2987	Length:	682	Species:	Danio rerio

Alignment Length:	434	Identity:	173/434 - (39%)
Similarity:	257/434 - (59%)	Gaps:	12/434 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 INIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGIT 72
            :|:|||||||:||||..|||:|..|.::|||:.|:|:||::.||.||.||||||:...||:||:|
Zfish   259 LNLVVIGHVDAGKSTLMGHLLYLLGNVNKRTMHKYEQEAKKAGKASFAYAWVLDETGEERDRGVT 323

  Fly    73 IDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHA 137
            :|:.:.||||....||::|||||:|||.|||||.:|||.|||:|.|..||||||....|||||||
Zfish   324 MDVGMTKFETDSKVVTLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFEAGGQTREHA 388

  Fly   138 LLAFTLGVKQLIVGVNKMDSTEPPYSEARYEEIKKEVSSYIKKIGYNPASVAFVPISGWHGDNML 202
            ||..:|||.||.|.|||||...  :.:.|::||..::..::|:.|:..:.|.:||.||..|:|:.
Zfish   389 LLVRSLGVTQLAVAVNKMDQVN--WQQERFQEIISKLGHFLKQAGFKDSDVFYVPTSGLSGENLT 451

  Fly   203 EPSEKMPWFKGWSVERKEGKAEGKCLIDALDAILPPQRPTDKPLRLPLQDVYKIGGIGTVPVGRV 267
            ..| |:.....|..        |.||::.:||..||||..:||.||.:.||:|..|.|....|::
Zfish   452 TKS-KVADLTAWYT--------GPCLVEQIDAFKPPQRSVEKPFRLCVSDVFKDQGSGFCVTGKI 507

  Fly   268 ETGLLKPGMVVNFAPVNLVTEVKSVEMHHEALTEAMPGDNVGFNVKNVSVKELRRGYVAGDSKNN 332
            |.|.::.|..|...|.|....||.:.:|.|||..|..||:|...|..:.:.::..|.|..|.| .
Zfish   508 EAGYIQTGDKVLAMPPNETCTVKGISLHDEALDWAAAGDHVSLTVTGMDIIKINVGCVFCDPK-E 571

  Fly   333 PPRGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFSEIKEKCDRRTGKTTETEPKAIKSG 397
            |.|....|.|::::.|....|..|:..:|...|........::.....:.:|:..:.:||.:..|
Zfish   572 PIRACTRFRARILLFNIELPITQGFPVLLHYQTVSEPATIRKLVSVLHKSSGEVLKKKPKCLSKG 636

  Fly   398 DAAIIVLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVGVIKSV 441
            ..|::.:...:|:.:|.::::..||||.:|.:..|:|.||:..:
Zfish   637 QNAVVEIQTQRPVAMELYKDYKELGRFMLRYVGSTIAAGVVTEI 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha2	NP_524611.1	PTZ00141	1..450	CDD:185474	173/434 (40%)
hbs1l	NP_001295477.1	HBS1_N	<78..130	CDD:286079
		TEF1	254..682	CDD:227581	173/434 (40%)
		EF1_alpha	260..479	CDD:206670	114/229 (50%)
		HBS1-like_II	485..568	CDD:293912	28/82 (34%)
		HBS1_C_III	572..680	CDD:294008	25/107 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820