DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF1alpha2 and GSPT1

DIOPT Version :9

Sequence 1:	NP_524611.1	Gene:	eEF1alpha2 / 43736	FlyBaseID:	FBgn0000557	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_002085.3	Gene:	GSPT1 / 2935	HGNCID:	4621	Length:	637	Species:	Homo sapiens

Alignment Length:	444	Identity:	171/444 - (38%)
Similarity:	261/444 - (58%)	Gaps:	17/444 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERE 68
            :|.|:|:|.|||||:||||..|.::|..|.:||||:||:|:||:|..:.::..:|.||..:.||:
Human   209 KKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERD 273

  Fly    69 RGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQT 133
            :|.|:::....|||.|.:.||:|||||:.|:.|||.|.||||.|||:::|..||||.|..|.|||
Human   274 KGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQT 338

  Fly   134 REHALLAFTLGVKQLIVGVNKMDSTEPPYSEARYEEIKKEVSSYIKKIGYNP-ASVAFVPISGWH 197
            ||||:||.|.|||.|||.:||||.....:|..||||.|:::..::||:|:|| ..:.|:|.||..
Human   339 REHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLT 403

  Fly   198 GDNMLEPSEKMPWFKGWSVERKEGKAEGKCLIDALDAILPPQRPTDKPLRLPLQDVYKIGGIGTV 262
            |.|:.|.|:..||:.|..            .|..||.:....|..|.|:|||:.|.||  .:|||
Human   404 GANLKEQSDFCPWYIGLP------------FIPYLDNLPNFNRSVDGPIRLPIVDKYK--DMGTV 454

  Fly   263 PVGRVETGLLKPGMVVNFAPVNLVTEVKSVEMHHEALTEAMPGDNVGFNVKNVSVKELRRGYVAG 327
            .:|::|:|.:..|..:...|.....||..:...........||:|:...:|.:..:|:..|::..
Human   455 VLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEEEEILPGFILC 519

  Fly   328 DSKNNPPRGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFSEIKEKCDRRTGKTTETEPK 392
            | .||.......|.||::::.|...|..||..||..||.....:.:.:....|:::|:.::|.|:
Human   520 D-PNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPR 583

  Fly   393 AIKSGDAAIIVLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVG-VIKSVNFKE 445
            .:|.....|..|..:..:|:|:|::||.:|||.:||..:|:|:| |:|.|..|:
Human   584 FVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha2	NP_524611.1	PTZ00141	1..450	CDD:185474	171/444 (39%)
GSPT1	NP_002085.3	PAM2	64..81	CDD:284542
GSPT1	NP_002085.3	TEF1	210..634	CDD:227581	169/438 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X149
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820