DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha2 and SPBC25B2.01

DIOPT Version :9

Sequence 1:	NP_524611.1	Gene:	eEF1alpha2 / 43736	FlyBaseID:	FBgn0000557	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001342767.1	Gene:	SPBC25B2.01 / 2540430	PomBaseID:	SPBC25B2.01	Length:	592	Species:	Schizosaccharomyces pombe

Alignment Length:	445	Identity:	169/445 - (37%)
Similarity:	244/445 - (54%)	Gaps:	42/445 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 INIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGIT 72
            :::||.|||||||||..|.::::.|.|:.|:::|...||...|||||.|||:||..:.||.||:|
pombe   178 VHLVVTGHVDSGKSTMLGRIMFELGEINSRSMQKLHNEAANSGKGSFSYAWLLDTTEEERARGVT 242

  Fly    73 IDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHA 137
            :|:|...||:.|....|.|||||||||..||.|.|.||.|||:|.:....||.|..:||||||||
pombe   243 MDVASTTFESDKKIYEIGDAPGHRDFISGMIAGASSADFAVLVVDSSQNNFERGFLENGQTREHA 307

  Fly   138 LLAFTLGVKQLIVGVNKMDSTEPPYSEARYEEIKKEVSSY-IKKIGYNPASVAFVPISGWHGDNM 201
            .|...||:.:::|.|||:|...  :||.|::|||..||.: ||.:|:..::|.|||||...|.|:
pombe   308 YLLRALGISEIVVSVNKLDLMS--WSEDRFQEIKNIVSDFLIKMVGFKTSNVHFVPISAISGTNL 370

  Fly   202 L--EPSEKMPWFKGWSVERKEGKAEGKCLIDALDAILPPQRPTDKPLRLPLQDVYKIGGIGTVPV 264
            :  :.|:...|:|            |..|:.|||.::||::|..|||||.:.|||:.....|| .
pombe   371 IQKDSSDLYKWYK------------GPTLLSALDQLVPPEKPYRKPLRLSIDDVYRSPRSVTV-T 422

  Fly   265 GRVETGLLKPGMVVNFAPVNLVTEVKSVEMHHE-ALTEAMPGDNVGFNVKNVSVKELRRGYVAGD 328
            ||||.|.::...|:..........||:|..:.: :.|.|:.||.|...:.::.|.:||.|.:..:
pombe   423 GRVEAGNVQVNQVLYDVSSQEDAYVKNVIRNSDPSSTWAVAGDTVTLQLADIEVNQLRPGDILSN 487

  Fly   329 SKNNPPRGAADFTAQVIVLNHPGQIANGYTPVLDCH----TAHIACKFSEIKEKCDRRTGKTTET 389
            .: ||.|....|.|::...:..|.|.:|.|.||  |    ...::.|...:..|..|.
pombe   488 YE-NPVRRVRSFVAEIQTFDIHGPILSGSTLVL--HLGRTVTSVSLKIVTVNNKRSRH------- 542

  Fly   390 EPKAIKSGDAAII---VLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVGVIKSV 441
                |.|...|::   .|....|||:.  :|.|.||||.:|....|||.|::|.:
pombe   543 ----IASRKRALVRISFLDGLFPLCLA--EECPALGRFILRRSGDTVAAGIVKEL 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha2	NP_524611.1	PTZ00141	1..450	CDD:185474	169/445 (38%)
SPBC25B2.01	NP_001342767.1	HBS1_N	<34..80	CDD:312481
SPBC25B2.01	NP_001342767.1	TEF1	171..592	CDD:227581	169/445 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X149
TreeFam	0	0.000	Not matched by this tool.
	4	3.810