DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha2 and erfa-3

DIOPT Version :9

Sequence 1:	NP_524611.1	Gene:	eEF1alpha2 / 43736	FlyBaseID:	FBgn0000557	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001256292.1	Gene:	erfa-3 / 179537	WormBaseID:	WBGene00010405	Length:	532	Species:	Caenorhabditis elegans

Alignment Length:	455	Identity:	167/455 - (36%)
Similarity:	264/455 - (58%)	Gaps:	43/455 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAE 66
            |..|.|||:|.:||||:||||..|.|::..|.:||||:||:|:||:|.|:.|:..:|.:|....|
Worm   104 GTHKEHINMVFVGHVDAGKSTIGGQLMFLTGMVDKRTLEKYEREAKEKGRESWYLSWCMDTNDEE 168

  Fly    67 RERGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNG 131
            ||:|.|:::....|||.|.:.||:|||||:.|:.|||.|.:|||.|||:::|..||||.|..:.|
Worm   169 REKGKTVEVGRAYFETEKRHFTILDAPGHKSFVPNMIVGANQADLAVLVISARRGEFETGFDRGG 233

  Fly   132 QTREHALLAFTLGVKQLIVGVNKMDSTEPPYSEARYEEIKKEVSSYIKKIGYNP-ASVAFVPISG 195
            |||||::|..|.|||.|::.|||||.....:.|.|::||:.:::.:::|:|:|| ..:.:||.||
Worm   234 QTREHSMLVKTAGVKHLVILVNKMDDPTVKWEEERFKEIEGKLTPFLRKLGFNPKTDITYVPCSG 298

  Fly   196 WHGDNMLEPSEKMPWFKGWSVERKEGKA----EGKCLIDALDAILPP-QRPTDKPLRLPLQDVYK 255
            ..|              .:..:|..|..    .|.|.|:.:|.:||. :|..:.|:|..:.:.|
Worm   299 LTG--------------AFIKDRPTGSEGNWYSGPCFIEFIDVLLPSYKRDFNGPVRCTVAEKY- 348

  Fly   256 IGGIGTVPVGRVETGLLKPG--MVV--NFAPVNLVTEVKSVEMHHEALTEAMPGDNVGFNVKNVS 316
             ..:|||.:|::|:|.::.|  :||  |..||. |.::.:.::..|   ..:.|||:.|.:|.:.
Worm   349 -SEMGTVIIGKMESGCVQKGDTLVVMPNKQPVQ-VLQIWADDVETE---RVVAGDNIKFKLKGIE 408

  Fly   317 VKELRRGYVAGDSKNNPPRGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFSEIKEK--- 378
            ..||:.|::.....:....|.. |.|:|:||.|...||:||:.||     ||.....|:..|
Worm   409 ENELQGGFIICSPDSLAKTGRV-FDAEVLVLEHRSIIASGYSCVL-----HIQSAVEEVTVKGVI 467

  Fly   379 --CDRRTGKTTETEPKAIKSGDAAIIVLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVGVIKSV 441
              .|::||:  :...|.:|..:..|:.|...:|..:|.|:|:|.||||.:||..:|:|:|.:..|
Worm   468 ATIDKKTGE--KKRAKFVKQDEKCIMRLESPEPFVLEPFKEYPYLGRFTLRDEGKTIAIGKVLKV 530

Fly 442 441
Worm 531 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha2	NP_524611.1	PTZ00141	1..450	CDD:185474	167/455 (37%)
erfa-3	NP_001256292.1	DUF959	24..>94	CDD:368758
erfa-3	NP_001256292.1	TEF1	105..532	CDD:227581	166/454 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X149
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920