DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF1alpha2 and HBS1L

DIOPT Version :9

Sequence 1:	NP_524611.1	Gene:	eEF1alpha2 / 43736	FlyBaseID:	FBgn0000557	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_006611.1	Gene:	HBS1L / 10767	HGNCID:	4834	Length:	684	Species:	Homo sapiens

Alignment Length:	443	Identity:	171/443 - (38%)
Similarity:	261/443 - (58%)	Gaps:	20/443 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAE 66
            ||:.  :|:|||||||:||||..||::|..|.|:|||:.|:|:|:::.||.||.||||||:...|
Human   257 GKQL--LNLVVIGHVDAGKSTLMGHMLYLLGNINKRTMHKYEQESKKAGKASFAYAWVLDETGEE 319

  Fly    67 RERGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNG 131
            ||||:|:|:.:.||||:...:|::|||||:|||.|||||.:|||.|||:|.|..||||||....|
Human   320 RERGVTMDVGMTKFETTTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGG 384

  Fly   132 QTREHALLAFTLGVKQLIVGVNKMDSTEPPYSEARYEEIKKEVSSYIKKIGYNPASVAFVPISGW 196
            |||||.||..:|||.||.|.|||||...  :.:.|::||..::..::|:.|:..:.|.|:|.||.
Human   385 QTREHGLLVRSLGVTQLAVAVNKMDQVN--WQQERFQEITGKLGHFLKQAGFKESDVGFIPTSGL 447

  Fly   197 HGDNML---EPSEKMPWFKGWSVERKEGKAEGKCLIDALDAILPPQRPTDKPLRLPLQDVYKIGG 258
            .|:|::   :.||...|:|            |.||::.:|:..||||..|||.||.:.||:|..|
Human   448 SGENLITRSQSSELTKWYK------------GLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQG 500

  Fly   259 IGTVPVGRVETGLLKPGMVVNFAPVNLVTEVKSVEMHHEALTEAMPGDNVGFNVKNVSVKELRRG 323
            .|....|::|.|.::.|..:...|.|....||.:.:|.|.:..|..||:|...:..:.:.::..|
Human   501 SGFCITGKIEAGYIQTGDRLLAMPPNETCTVKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINVG 565

  Fly   324 YVAGDSKNNPPRGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFSEIKEKCDRRTGKTTE 388
            .:....| .|.:....|.|::::.|....|..|:..:|...|.........:....::.||:.|:
Human   566 CIFCGPK-VPIKACTRFRARILIFNIEIPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTK 629

  Fly   389 TEPKAIKSGDAAIIVLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVGVIKSV 441
            .:||.:..|..|::.|...:|:.:|.:::|..||||.:|....|:|.||:..:
Human   630 KKPKFLTKGQNALVELQTQRPIALELYKDFKELGRFMLRYGGSTIAAGVVTEI 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha2	NP_524611.1	PTZ00141	1..450	CDD:185474	171/443 (39%)
HBS1L	NP_006611.1	HBS1_N	54..129	CDD:312481
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..241
		TEF1	256..684	CDD:227581	171/443 (39%)
		G1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	267..274		5/6 (83%)
		G2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	323..327		2/3 (67%)
		G3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	344..347		2/2 (100%)
		G4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	406..409		2/2 (100%)
		G5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	445..447		1/1 (100%)
		Interaction with the exosome complex. /evidence=ECO:0000269\|PubMed:28204585	546..572		4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820