DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1alpha2 and hbs1l

DIOPT Version :9

Sequence 1:	NP_524611.1	Gene:	eEF1alpha2 / 43736	FlyBaseID:	FBgn0000557	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	XP_012818243.1	Gene:	hbs1l / 100170572	XenbaseID:	XB-GENE-944105	Length:	677	Species:	Xenopus tropicalis

Alignment Length:	456	Identity:	171/456 - (37%)
Similarity:	260/456 - (57%)	Gaps:	32/456 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KEKIHI--------------NIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGS 53
            |:||:|              |:|||||||:||||..|||:|..|.::|||:.|:|:|:::.||.|
Frog   235 KQKINIKEELEKRQGGKHLLNLVVIGHVDAGKSTLMGHLLYLLGHVNKRTMHKYEQESKKAGKAS 299

  Fly    54 FKYAWVLDKLKAERERGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAA 118
            |.||||||:...||:||:|:|:.:.||||....:|::|||||:|||.|||||.:|||.|||.|.|
Frog   300 FAYAWVLDETGEERQRGVTMDVGMTKFETKSKVITLMDAPGHKDFIPNMITGAAQADVAVLAVDA 364

  Fly   119 GTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSTEPPYSEARYEEIKKEVSSYIKKIGY 183
            ..||||||....|||||||||..:|||.||.|.|||||...  :.:.|:.|:..::..::|:.|:
Frog   365 SRGEFEAGFEAGGQTREHALLVRSLGVTQLAVAVNKMDQVN--WQQERFNEVTSKLGHFLKQAGF 427

  Fly   184 NPASVAFVPISGWHGDNML---EPSEKMPWFKGWSVERKEGKAEGKCLIDALDAILPPQRPTDKP 245
            ..:.|.::|.||..|:|::   :.||.:.|:|            |.||::.:|....|||..|||
Frog   428 KESDVYYIPTSGLSGENLVKRSQISELINWYK------------GPCLLEQIDYFKAPQRSVDKP 480

  Fly   246 LRLPLQDVYKIGGIGTVPVGRVETGLLKPGMVVNFAPVNLVTEVKSVEMHHEALTEAMPGDNVGF 310
            .||...||:|..|.|....|::|.|.::.|..:...|.:....||.:.:|.||:..|..||:|..
Frog   481 FRLCTSDVFKDQGSGFCVTGKIEAGFVQTGDRLLAMPPHETCTVKGITLHEEAVDWAAAGDHVSL 545

  Fly   311 NVKNVSVKELRRGYVAGDSKNNPPRGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFSEI 375
            .:..:.:.::..|.|. .|.|.|.:....|.|:|::.|....|..|:..::...|........::
Frog   546 TLTGMDIIKINVGCVF-CSPNEPIKACTRFRARVLIFNFEVPITQGFPVLIHYQTVSEPATIRKL 609

  Fly   376 KEKCDRRTGKTTETEPKAIKSGDAAIIVLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVGVIKS 440
            .....:.||:..:.:||.:..|..|:|.|...:|:.:|.:::|..||||.:|....::|.||:..
Frog   610 VSVLHKSTGEVMKKKPKCLTKGMNAVIELQTQRPIALELYKDFKELGRFMLRYSGSSIAAGVVTE 674

  Fly   441 V 441
            :
Frog   675 I 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1alpha2	NP_524611.1	PTZ00141	1..450	CDD:185474	171/456 (38%)
hbs1l	XP_012818243.1	HBS1_N	<69..118	CDD:370196
hbs1l	XP_012818243.1	TEF1	254..677	CDD:227581	167/437 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	1	1.000	-	-		FOG0000314
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920