DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1815 and Zmynd11

DIOPT Version :9

Sequence 1:	NP_651881.2	Gene:	CG1815 / 43730	FlyBaseID:	FBgn0039863	Length:	1664	Species:	Drosophila melanogaster
Sequence 2:	XP_006516554.1	Gene:	Zmynd11 / 66505	MGIID:	1913755	Length:	673	Species:	Mus musculus

Alignment Length:	1116	Identity:	192/1116 - (17%)
Similarity:	316/1116 - (28%)	Gaps:	571/1116 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 PTPGW-----DPFCWKCRGCGKLMPCSKCLRSFHSYCVRPATTKFDSS--WKCPECQVIEAAPKR 395
            |...|     |.:|::|...|:::.|..|.|.:||.|:.......|||  |:||.|:.|:.....
Mouse   105 PNKDWETETHDWYCFECHLPGEVLICDLCFRVYHSKCLSDEFRLRDSSSHWQCPVCRSIKKKHSN 169

  Fly   396 LRRNGVSVDLLSQLLSFALDRMK------HVRGAHKLRSPLEVFPLTYKKFFVNPVSFESLAQCI 454
            .:..|.       .|.|.:.|||      :.:|... :.|:      |::...:.|...::.:.:
Mouse   170 KQEMGT-------YLRFIVSRMKERAIDLNKKGKDS-KHPM------YRRLVHSAVDVPTIQEKV 220

  Fly   455 RNGAYQSTDEFLSEVKWIQHNALILDAGDAKVEQASKAVVKVCRQEANEIDTCPEC-YLNANSSD 518
            ..|.|:|.:||.::.:.:.||.:|....|::....::.:.|....|.:|:..|..| ||:....|
Mouse   221 NEGKYRSYEEFKADAQLLLHNTVIFYGADSEQADIARMLYKDTCHELDELQLCKNCFYLSNARPD 285

  Fly   519 EWFVKVCRHPHLLLWAKLKGFPYWPAKAMGSSNSTLVNVRFFG-KHDRAFVPVKDCFLYSAQNPN 582
            .||...|...|.|:|||:|||.:||||.|...::. |:||||| .|.||::|          :.|
Mouse   286 NWFCYPCIPNHELVWAKMKGFGFWPAKVMQKEDNQ-VDVRFFGHHHQRAWIP----------SEN 339

  Fly   583 TQTSRRSARDLAECIREVEIHIDHIKRKIGAFNYAPYRTPYDPLEEQQQLEQMMPGVY---AAID 644
            .|       |:.     |.:|..|:||.:|      ::...|.||..|:.  :..|.:   ...|
Mouse   340 IQ-------DIT-----VNVHRLHVKRSMG------WKKACDELELHQRF--LREGRFWKSKNED 384

  Fly   645 RELEPANKTPLQFLIRKTADDKLSIVKKTKATESGNESDQSPSPTKKLSEVDVVSVTGSGCSDHS 709
            |..|.|..:     |..|::::|.:.::.:|.:  ...:||..|.|::|           |..||
Mouse   385 RGEEEAESS-----ISSTSNEQLKVTQEPRAKK--GRRNQSVEPKKEVS-----------CPPHS 431

  Fly   710 NVKSNNYEVISRSGESLTDSRCKVLLKR-KSLAAKIVAESVETSEAVAPKRKHSLSDASFTSESS 773
                                 .:|.::| |||..:
Mouse   432 ---------------------VQVAIERGKSLKVR------------------------------ 445

  Fly   774 EHKRKSKHARKQHDNQDNQIEEAEKTGQEPPKSPTISKQNENLRDEENVIENAANDTSSASPVSA 838
                                                |:|:.|:|           ...:.||.|.
Mouse   446 ------------------------------------SRQSSNIR-----------QVKAQSPDSC 463

  Fly   839 SVVSVVELVRRRQGVTITKIPREQQQTAEDTAAVPIPLPTAPPPKQNIPKGNEAANPKQSDVERQ 903
                       |.|:.:     :|..:|:
Mouse   464 -----------RCGLLL-----DQHASAQ------------------------------------ 476

  Fly   904 QEQLIKKVIPFIEIKTEVMSEPDDEGIEEASPANQPQTDQVPLQQETITAQPESQMPAAAPAPQP 968
                                                                       :|:|:|
Mouse   477 -----------------------------------------------------------SPSPEP 482

  Fly   969 KPVDNAPFEEVRIKEEILSEDEMETEQSIVSRRLKSVPPMPLPMPPPPPLPPREESPATADSVRF 1033
            :|                     |||....|   :.:|.||.|
Mouse   483 EP---------------------ETEAVSSS---QEIPTMPQP---------------------- 501

  Fly  1034 VGDTTIQRVSQKQGGKSTDTGGKRKGVQQVPIAGIPQAPSPTHSPLLSTAPSPSASPKPTSTLAV 1098
                 |:|||                                    :||         .|..|:.
Mouse   502 -----IERVS------------------------------------VST---------QTKKLSA 516

  Fly  1099 SKPPPPPPPKGKSASHLQFRGKNDRIPTSPPATAPPATNTSSLLRSNMVVIPVEQGGSCNAHSPM 1163
            |.|
Mouse   517 SSP-------------------------------------------------------------- 519

  Fly  1164 TIPVPPLRAVSKNTLQNTSTGSTSSCVPSSVSMPPPLAGLSIPPVATPTSQEESITNSGQPVGLL 1228
                   |.:.::| |.||.|
Mouse   520 -------RMLHRST-QTTSDG-------------------------------------------- 532

  Fly  1229 ASALNGTANDVLSSDSIPNDPITPGLATALSEMLLHTGVPKLIARPRGALRSDGSQIYPSQAGPV 1293
                                         :.:.:.|....|:....:..::||.
Mouse   533 -----------------------------VCQSMCHDKYTKIFNDFKDRMKSDH----------- 557

  Fly  1294 SQKLKENAHKITDYFISVIEDTLSDMATGDQSVLQARIAGLSLENERLKQHYDRQINDLHRTSEL 1358
                |....::..   ..:|...|:|....:..:...:|.|..:.:|    ..:|:.:  :..|.
Mouse   558 ----KRETERVVR---EALEKLRSEMEEEKRQAVNKAVASLQGDMDR----KGKQLKE--KCKEE 609

  Fly  1359 MISEMRKTLEQEHKRVISELRQQNAIELMRAVEEAKRKQWCANCMREAQLYCCWNTSYCDYPCQQ 1423
            .:.|::| |..:||::||               :.|:||||.||..||..:||||||||...|||
Mouse   610 FVEEIKK-LAAQHKQLIS---------------QTKKKQWCYNCEEEAMYHCCWNTSYCSIKCQQ 658

  Fly  1424 LHWPG-HSATC 1433
            .||.. |..||
Mouse   659 EHWHAEHKRTC 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1815	NP_651881.2	PHD_PRKCBP1	345..386	CDD:277013	15/42 (36%)
		Bromo_RACK7	403..501	CDD:99940	19/103 (18%)
		BS69_related	520..603	CDD:99902	30/83 (36%)
		zf-MYND	1399..1433	CDD:280009	19/34 (56%)
		Med3	<1428..1664	CDD:288447	3/7 (43%)
Zmynd11	XP_006516554.1	PHD_BS69	117..160	CDD:277012	15/42 (36%)
		Bromo_ZMYND11	173..273	CDD:99924	22/113 (19%)
		BS69_related	287..368	CDD:99902	38/109 (35%)
		zf-MYND	634..669	CDD:366792	19/34 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3612
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D183667at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3824
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850