DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1815 and zmynd8

DIOPT Version :9

Sequence 1:	NP_651881.2	Gene:	CG1815 / 43730	FlyBaseID:	FBgn0039863	Length:	1664	Species:	Drosophila melanogaster
Sequence 2:	XP_692886.6	Gene:	zmynd8 / 564460	ZFINID:	ZDB-GENE-041119-1	Length:	1201	Species:	Danio rerio

Alignment Length:	1334	Identity:	333/1334 - (24%)
Similarity:	543/1334 - (40%)	Gaps:	344/1334 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 SGEGESSLFSDASDTKTTTAKTP-------EEEAAERLALIYEEPPTPGWDP------------F 345
            |..|.|.  |::|.:.....|.|       ::.........|.:.|....||            :
Zfish    49 SSNGHSP--SESSPSPVKKKKKPGAVNSSKDQSELRHGPFYYVKQPALTTDPVDVVPQDGRNDFY 111

  Fly   346 CWKCRGCGKLMPCSKCLRSFHSYCVRPATTKFDSSWKCPEC------QVIEAAPKRLRRNGVSVD 404
            ||.|...|:::.|..|.|.:|:.|::.|... :..|.||||      :.||...|.:..  :::|
Zfish   112 CWVCHREGQVLCCELCPRVYHAKCLKLAAEP-EGDWFCPECEKITVAECIETQSKAMTM--LTLD 173

  Fly   405 LLSQLLSFALDRMKHVRGAHKLRSP--LEVFPLTYKKFFVNPVSFESLAQCIRNGAYQSTDEFLS 467
            .||.||.|||.:||. .|....:.|  ||..| .|.::..:.:...:|.:.|:...|.||:.||:
Zfish   174 QLSFLLKFALQKMKQ-PGTEPFQKPVSLEQHP-DYAEYIFHAMDICTLEKNIKKKMYGSTEAFLA 236

  Fly   468 EVKWIQHNALILDAGDAKVEQASKAVVKVCRQEANEIDTCPECYLNA-NSSDEWFVKVCRHPHLL 531
            :||||.||.:|.:.|:.|:...:|.:||:|..|.|||:.||||||:| ...|.||.:.|.:||.|
Zfish   237 DVKWILHNCIIYNGGNHKLTATAKVIVKICEHEMNEIEVCPECYLSACQKRDNWFCEPCSNPHPL 301

  Fly   532 LWAKLKGFPYWPAKAMGSSNSTLVNVRFFGKHDRAFVPVKDCFLYSAQNPNTQTSRRSARDLAEC 596
            :||||||||:|||||:...:.. |:.||||:||||:||:.:|:|.|.:.|.:....:|..:.|
Zfish   302 VWAKLKGFPFWPAKALRDKDGQ-VDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSA-- 363

  Fly   597 IREVEIHIDHIKRKIGAFNYAPYRTPYDPLEEQQQLEQMMPGVYAAIDRELEPAN---------- 651
            ::|:|:::::|::|.|.|||||:||||.|..:.|.|              |:|||
Zfish   364 MQEMEVYVENIRKKFGVFNYAPFRTPYTPDNQFQML--------------LDPANPSAGSVKPEK 414

  Fly   652 KTPLQFLIRKTADDKLSIVKKTKATESG-----NESDQSPSPTKKLSEVDVVSVTGSGCSD---- 707
            :..::|....||..||.:.|...::.||     :.:|...||....|...    |||....
Zfish   415 QEKIKFNFDVTASPKLLVGKSMVSSGSGTGRRISMTDMPRSPMSTNSSAH----TGSDGEQETAE 475

  Fly   708 --HSNVKSNNYE------------VISRSGESL----------------------TDSRCKVLLK 736
              |:.....:|.            ..||:|.:|                      |.|...:.|.
Zfish   476 KGHAKAALPHYSTGEESQDCTASPASSRAGSTLESPKPFHSPAPNTPVKQEKTPTTGSILNLNLD 540

  Fly   737 RK--SLAAKIVAESVETSEA-----VAPKR----------------------------------K 760
            |.  .:..|.::|||:..:.     .:|||                                  :
Zfish   541 RSKAEMDLKELSESVQQQQGAQPSLTSPKRQIRSRFQLNLDKTIESCKAQLGIDEISEDVYKGVE 605

  Fly   761 HSLSDASFTSESSEHKRKSKHARKQHDNQDNQIEEAEKTGQEPPKSPTISKQNENL-RDEENVIE 824
            ||.|:.|..|:||:.:..|:..:|..:.|:|:....:|..:||||..  ||.:... .|::...|
Zfish   606 HSDSEESDKSDSSDSEYGSEDEQKSKNGQNNKTTAEDKKEKEPPKKK--SKPSAAAGEDKDTSKE 668

  Fly   825 NAANDTSSASPVSASVVSVVELVRR-RQGVTITKIPREQQQTAEDTAAVPIPLPTAPPPKQNIPK 888
            ::|..::.|...:....|..:|:.: :.|:...|.|.|:.:.|          |.:|..::....
Zfish   669 SSATASTKAKAETGQKTSTPDLIAKDKSGMDSEKEPPEKLKAA----------PASPDAREKGKS 723

  Fly   889 GNEAANPKQSDVERQQEQLIKKVIPFIEIKTEVMSEPDDEGIEEASPANQPQTDQVPLQQETITA 953
            ..||:.|...||:...:...:.||...|          ::..:|...:.:.......|::.|.:.
Zfish   724 SEEASQPASVDVDMDSDSERELVIDLGE----------EQAGKERKRSRKDSAAVTALKEPTASK 778

  Fly   954 QPESQMPAAAPAPQPKPVDNAPFEEVRIKEEILSEDEMETEQSIVSRRLKSVPPMPLPMPPPPPL 1018
            ......|..:...||                          |:.|   |.|.|.|..|...|..:
Zfish   779 SEGKTTPITSSLTQP--------------------------QNTV---LSSSPTMKDPSQSPMAV 814

  Fly  1019 PPREESPATADSVRFVGDTTIQRVSQKQGGKSTDTGGKRKGVQQVPIAGIPQAPSPTHS--PLLS 1081
            |                                        :..:|:.|...:.|.|.|  |:.:
Zfish   815 P----------------------------------------LNIIPLTGAASSTSLTSSTLPIST 839

  Fly  1082 TAPSPSASPKPTSTLAVSKPPPP--------------PPPKGKSAS---HLQFRGKNDRIPTSPP 1129
            .:.:.|:||..|||:...:|..|              |..|.:::|   |:|      ::.....
Zfish   840 ASTASSSSPINTSTVKKQRPLLPRETVPVVQQAVVWNPSTKFQTSSQKWHMQ------KVQRQQQ 898

  Fly  1130 ATAPPATNTSSLLRSNMVVIPVEQGGSCNAHSPMTIPVPPLRAVSKNTLQNTSTGSTSSCVPSSV 1194
            ....|||....|.:......|.:|.                 .||.::....::.||......|:
Zfish   899 GQTQPATQAQVLTQVERNQQPQQQA-----------------QVSSSSSGQQASSSTRYQTRQSM 946

  Fly  1195 SMPPPLAGLSIPPVATPTSQEESITNSGQPVGLLASALNGTANDVLSSDSIPNDPITPGLATALS 1259
            .:                .::.|.|.|...|.|:.|                    ||..||.::
Zfish   947 KV----------------QKDSSHTTSTSAVTLVTS--------------------TPVSATIMA 975

  Fly  1260 EMLLHTGVPKLIARPRGALRSDGSQIYPSQAGPVSQKLKENAHKITDYFISVIEDTLSDMATGDQ 1324
            ...:.:......|         |....|:.:..|:..:.:..:||.|.....:.:..:|:.....
Zfish   976 GSTVSSSSTSATA---------GDFQIPTTSADVAADIAKYTNKIMDAIKGTMNEIYNDLTKSTS 1031

  Fly  1325 SVLQARIAGLSLENERLKQHYDRQINDLHRTSELMISEMRKTLEQEHKRVISELRQQNAIELMRA 1389
            ....|.|..|.:|.|:|:..:.::::::....||.::|||::||||.:|:::|:::|..:|..:|
Zfish  1032 GNTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERERIVAEVKKQMEMEKQQA 1096

  Fly  1390 VEEAKRKQWCANCMREAQLYCCWNTSYCDYPCQQLHWPGHSATCGQSVPPTIPVPPSVPTPIIEP 1454
            |:|.|:|||||||.:||..|||||||||||||||.|||.|..:|.||...:.....|..:..:
Zfish  1097 VDETKKKQWCANCRKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATSSQQEQESEGSTDV-- 1159

  Fly  1455 GRAKAKVATPTATPSITNPSPSSQIMRTVAACPS 1488
                    ||.| |...|..|:|. ..||::.|:
Zfish  1160 --------TPKA-PGQPNNGPNSP-RETVSSTPA 1183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1815	NP_651881.2	PHD_PRKCBP1	345..386	CDD:277013	13/40 (33%)
		Bromo_RACK7	403..501	CDD:99940	36/99 (36%)
		BS69_related	520..603	CDD:99902	38/82 (46%)
		zf-MYND	1399..1433	CDD:280009	25/33 (76%)
		Med3	<1428..1664	CDD:288447	15/61 (25%)
zmynd8	XP_692886.6	TNG2	<11..154	CDD:227367	26/107 (24%)
		PHD_PRKCBP1	111..151	CDD:277013	13/40 (33%)
		Bromo_RACK7	172..270	CDD:99940	36/99 (36%)
		BS69_related	290..370	CDD:99902	38/82 (46%)
		DUF3544	449..639	CDD:288884	35/193 (18%)
		DUF1640	1011..>1102	CDD:285090	25/90 (28%)
		zf-MYND	1106..1140	CDD:280009	25/33 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576784
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	365	1.000	Inparanoid score	I2127
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D183667at33208
OrthoFinder	1	1.000	-	-		FOG0007933
OrthoInspector	1	1.000	-	-		otm26274
orthoMCL	1	0.900	-	-		OOG6_107396
Panther	1	1.100	-	-	O	PTHR46453
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4437
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.900