DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1815 and E130308A19Rik

DIOPT Version :9

Sequence 1:	NP_651881.2	Gene:	CG1815 / 43730	FlyBaseID:	FBgn0039863	Length:	1664	Species:	Drosophila melanogaster
Sequence 2:	XP_006537918.1	Gene:	E130308A19Rik / 230259	MGIID:	2442164	Length:	755	Species:	Mus musculus

Alignment Length:	658	Identity:	116/658 - (17%)
Similarity:	204/658 - (31%)	Gaps:	223/658 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   866 AEDTAAVPIPLPTAPPPKQNIPKGNEAANPKQS--DVERQQEQLIKKVIPFIEIKTEVMSEPD-- 926
            ::..:.:.:|..|...|.:..|     ..|.::  |..|.::          .......|||.
Mouse    82 SDSPSIIGVPSETQTSPVERYP-----GRPVKAKLDCNRTRD----------SCDFSYCSEPSEL 131

  Fly   927 DEGIEEASPANQ--PQTDQVPLQQETITAQPESQMPAAAPAPQPKPVDNAPFEEVRIKEEILSED 989
            ||.:||....|.  ....:..:..|....:|::|.|.:....:|..|.::....        |:.
Mouse   132 DEAVEEYEDENTLFDMVCESSVTDEDSDFEPQTQRPQSIARKRPGIVPSSIHSS--------SQG 188

  Fly   990 EM--ETEQSIVSRRLKSVPPMPLPMPPPPPLPPREESPATADSVRFVGDTTIQRVSQKQGGKSTD 1052
            :|  |....::.:::|.            .:|......|.|:....|....:......:....|.
Mouse   189 QMVDECSNDVIIKKIKQ------------EIPEDYYIVANAELTGGVDGPALSLTQMAKPKPQTH 241

  Fly  1053 TGGKRKGVQQVPIAGIPQAPSPTHSPL----LSTAPSPSASPKPTSTLAVSKPPP---PPPPKGK 1110
            .|....|..::    ||...|..::.|    ||.:||..:.|....|..||...|   ||...|.
Mouse   242 AGPSCVGSAKL----IPHVTSAINTELDPHILSASPSVISRPIIPKTARVSLASPNRGPPGAHGT 302

  Fly  1111 ----------SASH-----------LQFRGKNDRI------PTSPPATA------PPATNTSSLL 1142
                      |.||           ||..|:::::      |..|...:      .|:.||
Mouse   303 AHQVTMQMPVSTSHPNKQISIPLSALQLPGQDEQVASEEFLPHLPSQVSSCEVALSPSVNT---- 363

  Fly  1143 RSNMVVIPVEQGGSCNAHSPMTIPVPPLRAVSKNTLQNTSTGSTSSCVPSSVSMPPPLAGLSIPP 1207
                     |...|.:...|...|             ..:|.:|:.|:|.::...||....::|
Mouse   364 ---------EPEVSSSQQQPPAAP-------------TITTEATAQCIPVNIFTAPPRGIRTLP- 405

  Fly  1208 VATPTSQEESITNSG---------QPVGLLASA----------LNGTANDVLSSDSIPNDP---- 1249
                  :..::..|.         ..:|||:.:          :|...|.:.:|...||..
Mouse   406 ------EPGNVLCSSWRYLQGYYCMAIGLLSYSTKLNKFPVFNINDDLNGLCTSAVSPNTTKATR 464

  Fly  1250 ----------ITPGLATALSEMLLHTGVPKLIARPRGALRSDGSQIYPSQAGPVSQKLKENAHKI 1304
                      :|.||..       ||.:.|:.|                      .||.|   .:
Mouse   465 YALNVWRYWCMTNGLKD-------HTDITKIPA----------------------VKLNE---LL 497

  Fly  1305 TDYFISVIEDTLSD-MAT-------GDQSVLQARIAGLSLENERLKQHYDRQINDLHRTSELMIS 1361
            .:::::|.:...|| :||       |...:|:....|.|:                  ||....|
Mouse   498 ENFYVTVKKSDGSDFLATSLHAIRRGLDRILKNAGVGFSI------------------TSSTFSS 544

  Fly  1362 EMRKTLEQ---EHKRVISELRQQNAIELMRAVEEAKRKQWCANCMRE------AQLYCCWNTSYC 1417
            ..:|..|:   ..|..:|..|.:|.:....:.||   :.|.|.|:.:      ......:|:.|.
Mouse   545 STKKLKEKLWVLSKAGMSGARSRNIVYFSLSDEE---EMWQAGCLGDDSPITLLSTVVKYNSQYL 606

  Fly  1418 DYPCQQLH 1425
            :....|.|
Mouse   607 NMRTLQEH 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1815	NP_651881.2	PHD_PRKCBP1	345..386	CDD:277013
		Bromo_RACK7	403..501	CDD:99940
		BS69_related	520..603	CDD:99902
		zf-MYND	1399..1433	CDD:280009	6/33 (18%)
		Med3	<1428..1664	CDD:288447
E130308A19Rik	XP_006537918.1	DUF5585	<226..>386	CDD:375359	35/189 (19%)
E130308A19Rik	XP_006537918.1	DUF3504	577..725	CDD:371846	9/41 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3612
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900