DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1815 and zmynd11

DIOPT Version :9

Sequence 1:	NP_651881.2	Gene:	CG1815 / 43730	FlyBaseID:	FBgn0039863	Length:	1664	Species:	Drosophila melanogaster
Sequence 2:	NP_001096471.1	Gene:	zmynd11 / 100125090	XenbaseID:	XB-GENE-960939	Length:	604	Species:	Xenopus tropicalis

Alignment Length:	528	Identity:	115/528 - (21%)
Similarity:	218/528 - (41%)	Gaps:	110/528 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 EPPTPGWDPFCWKCRGCGKLMPCSKCLRSFHSYCVRPATTKFDSS--WKCPECQVIEAAPKRLRR 398
            |..|..|  :|::|...|::|.|.:|.|.:|..|:.......|||  |:||.|       |.:::
Frog    95 ETETHDW--YCFECHSPGEVMMCDQCFRVYHPKCLPDDLRLRDSSNHWQCPVC-------KSMKK 150

  Fly   399 NGVSVDLLSQLLSFALDRMK------HVRGAHKLRSPLEVFPLTYKKFFVNPVSFESLAQCIRNG 457
            ...:...:.:.:.|.:.|||      :.:|... :.|:      |::.....:...::.:.:..|
Frog   151 KNNTKQEMGKYMRFIVSRMKERAIELNKKGKDS-KHPM------YRRLVHTTIDVSTINEKVTEG 208

  Fly   458 AYQSTDEFLSEVKWIQHNALILDAGDAKVEQASKAVVKVCRQEANEIDTCPECYLNANSSDE-WF 521
            .|:|.|||.::.:.:.||.:|....|::....:|.:.|....|.:|:..|..|:..:|:..| ||
Frog   209 KYKSYDEFKADAQLLLHNTIIFYGDDSEQADVAKVLYKDTCHELDELQLCKNCFYLSNARPENWF 273

  Fly   522 VKVCRHPHLLLWAKLKGFPYWPAKAMGSSNSTLVNVRFFG-KHDRAFVPVKDCFLYSAQNPNTQT 585
            ...|...|.|:|||:|||.:||||.|...::. |:||||| .|.||::|
Frog   274 CYPCIPNHELVWAKMKGFGFWPAKVMQKEDNQ-VDVRFFGHHHQRAWIP---------------- 321

  Fly   586 SRRSARDLAECIRE--VEIHIDHIKRKIGAFNYAPYRTPYDPLEEQQQL---------------E 633
                    ::.|:|  |.:|..|:||.:|      ::...|.|:..|:.               |
Frog   322 --------SDNIQEITVNVHQLHVKRSMG------WKKACDELDLHQRFLREGRFWKSKGEEKGE 372

  Fly   634 QMMPGVYAAIDRELEPANKTPLQFLIRKTAD-----DKLSIVKKTKATESGNESDQSPSPTKKLS 693
            :......::...:...|::.|.....|:..:     ::.....:|:|..|..|....|.|.:|:|
Frog   373 EEAESSISSTSNDQHKASQEPRAKKGRRNQNVEPKKEEQEPEPETEAVSSSQEIPPVPPPVEKVS 437

  Fly   694 EVDVVSVTGSGCSDHSNVKSNNYEVISRSGESLTDSRC-----------------KVLLKRKSLA 741
            .          |:......:.:..::.||.::..|..|                 :|.:..|...
Frog   438 V----------CTQTKKPSAPSPRMLHRSTQTNNDLACQNMCHDKYSKIFNEYKERVGVDNKRET 492

  Fly   742 AKIVAESVETSEAVAPKRKHSLSDASFTSESSEHKRKSKHARKQHDNQDNQIEEAEKTGQEPPK- 805
            .::|.|:::.......:.|......:.::..:|..||.|..:::  .::..:||.:|...:..:
Frog   493 ERVVREALDKLRVEMEEEKRQAVSKAVSNAQAEMDRKCKQVKEK--CKEEFLEEIKKLAAQHKQL 555

  Fly   806 -SPTISKQ 812
             |.|..||
Frog   556 ISQTKKKQ 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1815	NP_651881.2	PHD_PRKCBP1	345..386	CDD:277013	15/42 (36%)
		Bromo_RACK7	403..501	CDD:99940	19/103 (18%)
		BS69_related	520..603	CDD:99902	29/85 (34%)
		zf-MYND	1399..1433	CDD:280009
		Med3	<1428..1664	CDD:288447
zmynd11	NP_001096471.1	PHD_BS69	102..145	CDD:277012	15/42 (36%)
		Bromo_ZMYND11	158..258	CDD:99924	21/106 (20%)
		BS69_related	272..353	CDD:99902	36/111 (32%)
		AtpF	472..>562	CDD:223783	14/91 (15%)
		zf-MYND	565..600	CDD:366792
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D183667at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3824
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950