DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek6 and SLITRK2

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001137475.1	Gene:	SLITRK2 / 84631	HGNCID:	13449	Length:	845	Species:	Homo sapiens

Alignment Length:	923	Identity:	187/923 - (20%)
Similarity:	304/923 - (32%)	Gaps:	261/923 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 CASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQV--LVLNDNHIPYLNREEFSTLGLLNLQRI 100
            |...|.|:......:..|.:...||:......:.::  |.||.|.:..|...||  :...|...:
Human    29 CKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEF--VNYSNAVTL 91

  Fly   101 YLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNPLKRLAAYQFPI 165
            :|..:.:|.|...:|..||.|..:.|::||||:|.:|||:|.:.|..|..:.|.:..:.|..|..
Human    92 HLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSK 156

  Fly   166 LPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLS-EYVFQHMANLKTLSLEENPWQC 229
            |..|:.|.::|.|:..: |.::....||..|:|:.|.|:.:. ..|.:|:..:..:.||||||.|
Human   157 LNKLKVLILNDNLLLSL-PSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNC 220

  Fly   230 NCKLRKFRGWYVNSRLSSVSLVCK----------------------------------------- 253
            .|.|...:.|.....:....:||:
Human   221 TCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASDSSQRGSHADTHVQRL 285

  Fly   254 -----------------GPPAQKDRTWDSV----DDELFG--------------CPPRVEIFNNE 283
                             .||..::|....|    |.:.||              ||......:
Human   286 SPTMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCTS-- 348

  Fly   284 EVQNIDIGSN--------TTFSCLVYGDPLPEVAWELNGKILDN--DNVLFESESIASDKLWSN- 337
              |:.|.|.|        |..|.|......|:..: |.|..|..  .|.|.|..|:....|.:|
Human   349 --QSSDNGLNVNCQERKFTNISDLQPKPTSPKKLY-LTGNYLQTVYKNDLLEYSSLDLLHLGNNR 410

  Fly   338 LTVF------NVTSLDA----GTYACTGSNSIGSMTQNIS-IYLSEIVQHVLEKTPETFWYFGLI 391
            :.|.      |:|||..    |.|......|:....|::. :||...|  :.|..|.||.....:
Human   411 IAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNV--IKEIKPLTFDALINL 473

  Fly   392 MGIFGTVFLLISIS---FVVCLCKRTTRQHRHANKAGVKSSVSFNDQEKKLLDSSVTTTTND-RG 452
            ..:|....||.|:.   |......|...::.|.:...||..:   ||....:...:.....| ..
Human   474 QLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVL---DQLPAFIQIDLQENPWDCTC 535

  Fly   453 DSYGID------NQPTSIGMNKGDSAGMGFNQIEIHAVESHRHGSMLVQQQPQQQQVAGGGGMRQ 511
            |..|:.      |.|..|            |::...:...|. |.:|        :..|...:..
Human   536 DIMGLKDWTEHANSPVII------------NEVTCESPAKHA-GEIL--------KFLGREAICP 579

  Fly   512 QLMQVKDSTCGMMS----VPTSMAGHAHSHPAQISEEFPLNVGVFPPPPEFCSNIVPNPAFGGNI 572
            ....:.|.|...|:    .|.|::....|:| ::..|.||:|.:......|..::    .||..:
Human   580 DSPNLSDGTVLSMNHNTDTPRSLSVSPSSYP-ELHTEVPLSVLILGLLVVFILSV----CFGAGL 639

  Fly   573 FIRVSVTQDMLDGADLNMYPDLLNIPKRMQDVQESGAGAVAVPEGQFATLPRHTARRGILKKDTS 637
            |:.|.                     ||.:.|               .::||:|....:    :|
Human   640 FVFVL---------------------KRRKGV---------------PSVPRNTNNLDV----SS 664

  Fly   638 LQQQ-----QQQHQQQHQHQQQQQQQQIQQ--QQHQQLQQQHQPSGLYTHDEIVTY-NLEASGYD 694
            .|.|     .:.|.:...|........:.|  |....:|::..|...|.:.:..:| |||....:
Human   665 FQLQYGSYNTETHDKTDGHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQEFSYSNLEEKKEE 729

  Fly   695 PHQSGYHSNAMELPPPPPPPAVTAVVQCHHPSPNNCASCINNAPPPPSA-------CQSPPVEVT 752
            |....|..:|.||......|....::.      .|.|..:...   |||       |..|..:..
Human   730 PATPAYTISATELLEKQATPREPELLY------QNIAERVKEL---PSAGLVHYNFCTLPKRQFA 785

  Fly   753 PMRPLDSSAYPKYDNMGRRITASGGLGGSNLSLHDEERYENETLFGQAESQTKGMPEQSQDLHQP 817
                      |.|::  ||              .:::|.....|:|                 .|
Human   786 ----------PSYES--RR--------------QNQDRINKTVLYG-----------------TP 807

  Fly   818 QEVTQGQDKGGGP 830
            ::...||.|...|
Human   808 RKCFVGQSKPNHP 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	7/26 (27%)
		LRR_8	96..155	CDD:290566	21/58 (36%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	11/22 (50%)
		LRR_4	144..186	CDD:289563	11/41 (27%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		leucine-rich repeat	169..216	CDD:275380	13/47 (28%)
		LRRCT	225..274	CDD:214507	16/124 (13%)
		Ig	295..367	CDD:143165	21/84 (25%)
SLITRK2	NP_001137475.1	LRR 1	63..84		7/22 (32%)
		leucine-rich repeat	67..87	CDD:275380	7/21 (33%)
		LRR_RI	<82..>217	CDD:238064	41/137 (30%)
		LRR_8	86..146	CDD:290566	21/59 (36%)
		LRR 2	87..108		5/20 (25%)
		leucine-rich repeat	88..111	CDD:275380	5/22 (23%)
		LRR 3	111..132		10/20 (50%)
		leucine-rich repeat	112..135	CDD:275380	11/22 (50%)
		LRR_8	135..193	CDD:290566	16/58 (28%)
		LRR 4	135..156		5/20 (25%)
		leucine-rich repeat	136..159	CDD:275380	6/22 (27%)
		LRR 5	159..180		5/21 (24%)
		leucine-rich repeat	160..181	CDD:275380	5/21 (24%)
		Required for interaction with PTPRD. /evidence=ECO:0000250\|UniProtKB:Q810C0	167..215		12/48 (25%)
		leucine-rich repeat	208..369	CDD:275380	26/164 (16%)
		TPKR_C2	216..>252	CDD:301599	9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..321		4/57 (7%)
		leucine-rich repeat	370..400	CDD:275380	8/30 (27%)
		LRR 7	376..397		6/21 (29%)
		LRR_8	399..459	CDD:290566	15/61 (25%)
		LRR 8	400..421		4/20 (20%)
		leucine-rich repeat	401..424	CDD:275380	4/22 (18%)
		LRR_4	423..466	CDD:289563	12/44 (27%)
		LRR 9	424..445		5/20 (25%)
		leucine-rich repeat	425..448	CDD:275380	4/22 (18%)
		LRR 10	448..469		7/22 (32%)
		leucine-rich repeat	449..468	CDD:275380	6/20 (30%)
		LRR 11	472..493		5/20 (25%)
		leucine-rich repeat	473..491	CDD:275380	4/17 (24%)
		LRR 12	495..516		4/23 (17%)
		leucine-rich repeat	496..509	CDD:275378	2/12 (17%)
		leucine-rich repeat	521..533	CDD:275378	0/11 (0%)
		LRRCT	529..579	CDD:214507	11/70 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000