DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and LRFN3

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_078785.1	Gene:	LRFN3 / 79414	HGNCID:	28370	Length:	628	Species:	Homo sapiens

Alignment Length:	393	Identity:	96/393 - (24%)
Similarity:	159/393 - (40%)	Gaps:	62/393 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ILLCLVAWTVADDWSLS-----CASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNH 80
            :||||:....|.....|     |...|.|:..:...|.:|....|..:|.:|......|.|.||.
Human     6 LLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNF 70

  Fly    81 IPYLNREEFSTL-GLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDR 144
            |..:.|.:.:.: |||:|.   |.::.::::...:|.:|:.|..:.|..|:|..|.:....|...
Human    71 IASVRRRDLANMTGLLHLS---LSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVN 132

  Fly   145 LRILYLNGNPLKRLAA--------------------YQFP-----ILPHLRTLDMHDCLISYIDP 184
            ||.|.|:.|.|..|||                    .|.|     .|.::.||.:...|::.:..
Human   133 LRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPA 197

  Fly   185 MSLANLNLLEFLNLKNNLLESL-SEYVFQHM----------ANLKTLSLEENPWQCNCKLRKFRG 238
            .:.:.|:.|..|::.:|.|.:: .:.:|..:          |:...|:...||..|||:|...|.
Human   198 GAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRR 262

  Fly   239 WYVNSRLSSVSLVCKGPPAQKDRTWDSVDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGD 303
            ......|.:    |..|||...|.:.:|.:|.|.|.|.| :.:......:..|......|...||
Human   263 LAREDDLEA----CASPPALGGRYFWAVGEEEFVCEPPV-VTHRSPPLAVPAGRPAALRCRAVGD 322

  Fly   304 PLPEVAW-ELNGKILDNDNVLFESESIASDKLWSNLTV-FNVTSL-DAGTYACTGSNSIGSMTQN 365
            |.|.|.| ...|::|.|.         :..:.:.|.|: ..||.. |.|.:.|..:|:.|..|..
Human   323 PEPRVRWVSPQGRLLGNS---------SRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAA 378

  Fly   366 ISI 368
            :.:
Human   379 VEL 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	8/25 (32%)
		LRR_8	96..155	CDD:290566	15/58 (26%)
		leucine-rich repeat	97..120	CDD:275380	4/22 (18%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_4	144..186	CDD:289563	15/66 (23%)
		leucine-rich repeat	145..168	CDD:275380	12/47 (26%)
		leucine-rich repeat	169..216	CDD:275380	9/57 (16%)
		LRRCT	225..274	CDD:214507	16/48 (33%)
		Ig	295..367	CDD:143165	20/74 (27%)
LRFN3	NP_078785.1	LRR_8	59..119	CDD:290566	16/62 (26%)
		LRR 1	60..83		6/22 (27%)
		LRR_RI	<63..168	CDD:238064	28/107 (26%)
		leucine-rich repeat	63..84	CDD:275380	6/20 (30%)
		LRR 2	84..105		6/23 (26%)
		leucine-rich repeat	85..108	CDD:275380	6/25 (24%)
		LRR 3	108..129		5/20 (25%)
		leucine-rich repeat	109..132	CDD:275380	6/22 (27%)
		LRR 4	132..153		9/20 (45%)
		leucine-rich repeat	133..157	CDD:275380	9/23 (39%)
		LRR_8	157..216	CDD:290566	10/58 (17%)
		LRR 5	157..178		2/20 (10%)
		leucine-rich repeat	158..181	CDD:275380	3/22 (14%)
		LRR 6	181..202		3/20 (15%)
		leucine-rich repeat	182..205	CDD:275380	4/22 (18%)
		LRR 7	205..226		4/20 (20%)
		leucine-rich repeat	206..230	CDD:275380	5/23 (22%)
		leucine-rich repeat	242..253	CDD:275378	3/10 (30%)
		TPKR_C2	249..>281	CDD:301599	12/35 (34%)
		IG_like	302..383	CDD:214653	21/89 (24%)
		Ig	310..383	CDD:299845	21/81 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..430		96/393 (24%)
		fn3	424..502	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4688
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960