DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and LRFN4

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001350453.1	Gene:	LRFN4 / 78999	HGNCID:	28456	Length:	635	Species:	Homo sapiens

Alignment Length:	385	Identity:	102/385 - (26%)
Similarity:	162/385 - (42%)	Gaps:	60/385 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLN 85
            :||.|:|...|     :|...|.|:..:...|.:|:...|..:|..:......|.|.||.|..|.
Human     5 LLLLLLASGAA-----ACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALG 64

  Fly    86 REEFSTL-GLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILY 149
            ..:|..: ||::|.   |.::.:..|...:|.:|:.|..:.|..|:|..|...:..|...|:.|.
Human    65 PPDFRNMTGLVDLT---LSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQHLI 126

  Fly   150 LNGNPLKRLA----------------AY----QFP-----ILPHLRTLDMHDCLISYIDPMSLAN 189
            |:||.|.|:|                :|    |.|     .:|.|.||::...||..:.|.:.|.
Human   127 LSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDALPPGAFAQ 191

  Fly   190 LNLLEFLNLKNNLLESLS-EYVFQHMANLK------TLSLEENPWQCNCKLRKFRGWYVNSRLSS 247
            |..|..|:|.:|.|.:|: :.:|....:.:      .||...||..|||:|...|      ||:.
Human   192 LGQLSRLDLTSNRLATLAPDPLFSRGRDAEASPAPLVLSFSGNPLHCNCELLWLR------RLAR 250

  Fly   248 VS--LVCKGPPAQKDRTWDSVDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAW 310
            ..  ..|..||....|.:.:|.:..|.|.|.:...:.:.:..:: |...|..|...|||.|.:.|
Human   251 PDDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQRLWVLE-GQRATLRCRALGDPAPTMHW 314

  Fly   311 ELNGKILDNDNVLFESESIASDKLWSNLTV-FNVTSL-DAGTYACTGSNSIGSMTQNISI 368
                  :..|:.|..:.|.|  :.:.|.|: ..||.. |||.|.|..:|..|..|..:.:
Human   315 ------VGPDDRLVGNSSRA--RAFPNGTLEIGVTGAGDAGGYTCIATNPAGEATARVEL 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	9/25 (36%)
		LRR_8	96..155	CDD:290566	16/58 (28%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_4	144..186	CDD:289563	18/66 (27%)
		leucine-rich repeat	145..168	CDD:275380	11/47 (23%)
		leucine-rich repeat	169..216	CDD:275380	15/47 (32%)
		LRRCT	225..274	CDD:214507	15/50 (30%)
		Ig	295..367	CDD:143165	23/73 (32%)
LRFN4	NP_001350453.1	LRR_8	48..108	CDD:316378	17/62 (27%)
		LRR 1	49..70		7/20 (35%)
		leucine-rich repeat	50..73	CDD:275380	7/22 (32%)
		LRR 2	73..94		6/23 (26%)
		leucine-rich repeat	74..97	CDD:275380	6/25 (24%)
		LRR_8	97..157	CDD:316378	15/59 (25%)
		LRR 3	97..118		5/20 (25%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		LRR 4	121..142		8/20 (40%)
		leucine-rich repeat	122..146	CDD:275380	8/23 (35%)
		LRR_8	146..205	CDD:316378	16/58 (28%)
		LRR 5	146..161		2/14 (14%)
		leucine-rich repeat	147..170	CDD:275380	3/22 (14%)
		LRR 6	170..191		6/20 (30%)
		leucine-rich repeat	171..194	CDD:275380	8/22 (36%)
		LRR 7	194..215		6/20 (30%)
		leucine-rich repeat	195..213	CDD:275380	6/17 (35%)
		LRRCT	234..278	CDD:214507	15/49 (31%)
		Ig_2	295..368	CDD:143241	24/80 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..410
		fn3	409..478	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..583
		PDZ-binding	632..635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4688
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960