DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and Cpn2

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_082180.2	Gene:	Cpn2 / 71756	MGIID:	1919006	Length:	547	Species:	Mus musculus

Alignment Length:	362	Identity:	90/362 - (24%)
Similarity:	150/362 - (41%)	Gaps:	48/362 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTE-----------LQVLVLNDNHIPYLNREEF 89
            |..::|...:...|...:: ||||...:.....||           |::|.|..|.|.:|....|
Mouse   198 LKLSNNMLARLPEGALGSL-SSLQELFLDGNAITELSPHLFSQLFSLEMLWLQHNAICHLPVSLF 261

  Fly    90 STLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNP 154
            |:|.  ||..:.||.:.::.:.:..|.:.:.|:.:.||.|:||.:.:..|....||..|.|:.|.
Mouse   262 SSLH--NLTFLSLKDNALRTLPEGLFAHNQGLLHLSLSYNQLETIPEGAFTNLSRLVSLTLSHNA 324

  Fly   155 LKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQHMANLKT 219
            :..|..:.|..|..|..|.:....::.:.|....||:.|:.|||..|.|.:|...:|....:|..
Mouse   325 ITDLPEHVFRNLEQLVKLSLDSNNLTALHPALFHNLSRLQLLNLSRNQLTTLPGGIFDTNYDLFN 389

  Fly   220 LSLEENPWQCNCKLRKFRGW--YVNSRLSSVSLVCKGPPAQKDRTWDSVDDELFGCPPRVEIFNN 282
            |:|..|||||:|.|.....|  ..|:::|:....|.||...|.:...::..|...||
Mouse   390 LALLGNPWQCDCHLSYLTSWLRLYNNQISNTHTFCAGPAYLKGQLVPNLKQEQLICP-------- 446

  Fly   283 EEVQNIDIGSNTTFSCLVYGDPLPEVAWEL--NGKILDND--------NVLFESESIASDKLWSN 337
                 ::.| :.:|..|...:..|..:|:|  .|:...:.        .||...|.  |...|.|
Mouse   447 -----VNPG-HLSFRALGLDEGEPAGSWDLTVEGRAAHSQCAYSNPEGTVLLACEE--SRCRWLN 503

  Fly   338 LTVFNVTSLDAGTYACTGS------NSIGSMTQNISI 368
            :.:.:....|:.......|      :|.|.:...:||
Mouse   504 IQLSSRDGSDSAAMVYNSSQEWGLRSSCGLLRVTVSI 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	9/24 (38%)
		LRR_8	96..155	CDD:290566	17/58 (29%)
		leucine-rich repeat	97..120	CDD:275380	4/22 (18%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_4	144..186	CDD:289563	11/41 (27%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		leucine-rich repeat	169..216	CDD:275380	13/46 (28%)
		LRRCT	225..274	CDD:214507	15/50 (30%)
		Ig	295..367	CDD:143165	16/87 (18%)
Cpn2	NP_082180.2	LRRNT	21..52	CDD:214470
		LRR_8	73..133	CDD:290566
		leucine-rich repeat	75..98	CDD:275380
		LRR 1	98..119
		leucine-rich repeat	99..122	CDD:275380
		LRR_8	121..181	CDD:290566
		LRR 2	122..143
		leucine-rich repeat	123..146	CDD:275380
		LRR 3	146..167
		leucine-rich repeat	147..170	CDD:275380
		LRR_RI	149..374	CDD:238064	48/178 (27%)
		LRR 4	170..191
		LRR_8	171..229	CDD:290566	7/31 (23%)
		leucine-rich repeat	171..194	CDD:275380
		LRR 5	194..215		3/16 (19%)
		leucine-rich repeat	195..218	CDD:275380	3/20 (15%)
		LRR_8	217..277	CDD:290566	19/61 (31%)
		LRR 6	218..239		5/20 (25%)
		leucine-rich repeat	219..242	CDD:275380	4/22 (18%)
		LRR 7	242..263		7/20 (35%)
		leucine-rich repeat	243..266	CDD:275380	9/24 (38%)
		LRR_8	266..325	CDD:290566	17/58 (29%)
		LRR 8	266..287		5/20 (25%)
		leucine-rich repeat	267..290	CDD:275380	4/22 (18%)
		LRR 9	290..311		7/20 (35%)
		leucine-rich repeat	291..314	CDD:275380	7/22 (32%)
		LRR_8	313..373	CDD:290566	18/59 (31%)
		LRR 10	314..335		7/20 (35%)
		leucine-rich repeat	315..338	CDD:275380	7/22 (32%)
		LRR 11	338..359		3/20 (15%)
		leucine-rich repeat	339..360	CDD:275380	3/20 (15%)
		LRR 12	362..383		8/20 (40%)
		leucine-rich repeat	363..382	CDD:275380	7/18 (39%)
		LRRCT	395..436	CDD:214507	14/40 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000