DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek6 and Islr

DIOPT Version :9

Sequence 1:NP_001263151.1 Gene:kek6 / 43729 FlyBaseID:FBgn0039862 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_001119772.1 Gene:Islr / 686539 RGDID:1596359 Length:428 Species:Rattus norvegicus


Alignment Length:383 Identity:85/383 - (22%)
Similarity:155/383 - (40%) Gaps:75/383 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 LCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNRE 87
            |||:.|.|..:...:|...|.|....|.:.|.|:...|..:|......:..|.|:.|.:|.|...
  Rat     4 LCLLCWVVLLNLVRACPEACDCGEKYGFQIADCAYRDLDGVPPGFPANVTTLSLSANRLPVLLEG 68

  Fly    88 EFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNG 152
            .|..:.|  ||.::|..:|::.:...:...|..|..:|||.|.:     ..|..:|         
  Rat    69 SFREVPL--LQSLWLAHNEIRSVAVGALAPLGHLKSLDLSHNLI-----SEFAWSD--------- 117

  Fly   153 NPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQHMANL 217
              |..|:|.|      |..:|.::  :::|...:..:|:.|..|.|.:|.|.:|:|..|..:.:|
  Rat   118 --LHNLSALQ------LLKMDSNE--LAFIPRDAFRSLHALRSLQLNHNRLHALAEGTFAPLTSL 172

  Fly   218 KTLSLEENPWQCNCKLRKFRGWYVNSRLS---SVSLVCKGPPAQKDRTWDSVDDELFGCP----- 274
            ..|.:..||:.|.|.:..|:.|.:.:.:|   ..::.|..|...|            |.|     
  Rat   173 SHLQINHNPFDCTCGIVWFKTWALATAVSIPEQDNIACTSPHVLK------------GTPLSRLP 225

  Fly   275 ------PRVEIFNNEEVQNIDI--GSNTTFSCLVYGDPLPEVAWELNGKILDNDNVLFESESIAS 331
                  |.|::.........::  |......|.|.|.|:|::.|.::   .....|...|.::.:
  Rat   226 PLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPVPQLHWHIH---TPGGTVEIASPNVGT 287

  Fly   332 D----------------KLWSN--LTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLS 371
            |                :.::|  |.:.:...|:.|||:|..:|.:||...::::.|:
  Rat   288 DGRPLPGALAASGQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVNVALA 345

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek6NP_001263151.1 leucine-rich repeat 71..96 CDD:275380 7/24 (29%)
LRR_8 96..155 CDD:290566 12/58 (21%)
leucine-rich repeat 97..120 CDD:275380 5/22 (23%)
leucine-rich repeat 121..144 CDD:275380 6/22 (27%)
LRR_4 144..186 CDD:289563 7/41 (17%)
leucine-rich repeat 145..168 CDD:275380 4/22 (18%)
leucine-rich repeat 169..216 CDD:275380 12/46 (26%)
LRRCT 225..274 CDD:214507 11/51 (22%)
Ig 295..367 CDD:143165 19/89 (21%)
IslrNP_001119772.1 leucine-rich repeat 32..51 CDD:275380 4/18 (22%)
LRR_8 51..110 CDD:404697 17/60 (28%)
leucine-rich repeat 52..75 CDD:275380 6/22 (27%)
leucine-rich repeat 76..99 CDD:275380 5/22 (23%)
LRR_8 99..158 CDD:404697 19/82 (23%)
leucine-rich repeat 100..123 CDD:275380 9/38 (24%)
leucine-rich repeat 124..147 CDD:275380 5/30 (17%)
leucine-rich repeat 148..171 CDD:275380 8/22 (36%)
PCC 153..>227 CDD:188093 20/85 (24%)
Ig 239..343 CDD:416386 20/106 (19%)
Ig strand C 265..287 CDD:409353 4/24 (17%)
Ig strand C' 288..290 CDD:409353 1/1 (100%)
Ig strand D 304..307 CDD:409353 0/2 (0%)
Ig strand E 310..316 CDD:409353 1/5 (20%)
Ig strand F 323..331 CDD:409353 4/7 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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