DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and RTN4R

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_075380.1	Gene:	RTN4R / 65078	HGNCID:	18601	Length:	473	Species:	Homo sapiens

Alignment Length:	307	Identity:	79/307 - (25%)
Similarity:	119/307 - (38%)	Gaps:	60/307 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VCWILLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIP 82
            :.|: |.|.||.||    ..|...|.| :...|.:..|....|..:|..:....|.:.|:.|.|.
Human    12 LAWV-LWLQAWQVA----APCPGACVC-YNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRIS 70

  Fly    83 YLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDN-KLEMLDKDTFMGNDR-- 144
            ::....|.  ...||..::|..:.:..|...:|..|.:|.::||||| :|..:|..||.|..|
Human    71 HVPAASFR--ACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLH 133

  Fly   145 ----------------------LRILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSL 187
                                  |:.|||..|.|:.|....|..|.:|..|.:|...||.:...:.
Human   134 TLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAF 198

  Fly   188 ANLNLLEFLNLKNNLLESLSEYVFQHMANLKT------------------------LSLEENPWQ 228
            ..|:.|:.|.|..|.:..:..:.|:.:..|.|                        |.|.:|||.
Human   199 RGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWV 263

  Fly   229 CNCKLRKFRGWYVNSRLSSVSLVCKGPP--AQKDRTWDSVDDELFGC 273
            |:|:.|....|....|.||..:.|..|.  |.:|....:.:| |.||
Human   264 CDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAAND-LQGC 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	5/24 (21%)
		LRR_8	96..155	CDD:290566	23/83 (28%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	11/23 (48%)
		LRR_4	144..186	CDD:289563	15/65 (23%)
		leucine-rich repeat	145..168	CDD:275380	9/22 (41%)
		leucine-rich repeat	169..216	CDD:275380	11/46 (24%)
		LRRCT	225..274	CDD:214507	18/51 (35%)
		Ig	295..367	CDD:143165
RTN4R	NP_075380.1	LRR 1. /evidence=ECO:0000255	55..79		5/25 (20%)
		leucine-rich repeat	60..82	CDD:275380	5/23 (22%)
		LRR 2. /evidence=ECO:0000255	81..103		5/21 (24%)
		LRR_8	82..142	CDD:338972	18/59 (31%)
		leucine-rich repeat	83..106	CDD:275380	5/22 (23%)
		LRR 3. /evidence=ECO:0000255	104..128		11/23 (48%)
		leucine-rich repeat	107..131	CDD:275380	11/23 (48%)
		LRR 4. /evidence=ECO:0000255	129..152		1/22 (5%)
		leucine-rich repeat	132..155	CDD:275380	0/22 (0%)
		LRR 5. /evidence=ECO:0000255	153..176		8/22 (36%)
		LRR_8	156..214	CDD:338972	19/57 (33%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		LRR 6. /evidence=ECO:0000255	178..200		5/21 (24%)
		leucine-rich repeat	180..203	CDD:275380	6/22 (27%)
		LRR 7. /evidence=ECO:0000255	202..224		5/21 (24%)
		LRR_8	203..261	CDD:338972	9/57 (16%)
		leucine-rich repeat	204..227	CDD:275380	5/22 (23%)
		LRR 8. /evidence=ECO:0000255	225..248		2/22 (9%)
		leucine-rich repeat	228..251	CDD:275380	2/22 (9%)
		LRR 9. /evidence=ECO:0000255	250..273		8/22 (36%)
		TPKR_C2	260..>296	CDD:387596	13/35 (37%)
		DUF390	332..>417	CDD:282014
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910