Protein Alignment kek6 and LINGO3

DIOPT Version :9

• Sequence 1: NP_001263151.1
• Gene: kek6 / 43729
• FlyBaseID: FBgn0039862
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_001094861.1
• Gene: LINGO3 / 645191
• HGNCID: 21206
• Length: 592
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 108/502 - (21%)
• Similarity: 167/502 - (33%)
• Gaps: 171/502 - (34%)

  Fly    19 CWIL---LCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNH 80
            ||:.   |.|:....|...:..|.:.|.|  |...::..|:..:||.:|:.:..|.::|.|:.|.
Human     3 CWLCVLSLPLLLLPAAPPPAGGCPARCEC--TVQTRAVACTRRRLTAVPDGIPAETRLLELSRNR 65

  Fly    81 IPYLNREEFSTLGLL-------------------NLQR---IYLKKSEVQYIHKESFRNLKILVE 123
            |..||..:.:.|..|                   ||.|   :.|:.::::.|....|..|..|..
Human    66 IRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTL 130

  Fly   124 IDLSDNKLEMLDKDTF------------------------------------------------- 139
            :|||:|||.:|...||
Human   131 LDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLG 195

  Fly   140 ----MGNDRLR------------------------------------------------------ 146
                :|..|||
Human   196 HLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITA 260

  Fly   147 -------------ILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNL 198
                         .|.|:.||:..:....|..|..||.|.:...|::.::|.:...|..:..|||
Human   261 VPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNL 325

  Fly   199 KNNLLESLSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRLSSVSL-----VCKGPPAQ 258
            .||||.:|.|..|..:..|:||.::.||..|:|:|.    |.|..| .:::.     .|..|...
Human   326 SNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLL----WIVQRR-KTLNFDGRLPACATPAEV 385

  Fly   259 KDRTW----DSVDDELFGC-PPRVEIFNNEEVQNI--DIGSNTTFSCLVYGDPLPEVAWELNGKI 316
            :....    |||..|.|.| .|::   ....:|.:  ..|.:..|.|...|:|.|.|||...
Human   386 RGDALRNLPDSVLFEYFVCRKPKI---RERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTP--- 444

  Fly   317 LDNDNVLFESESIASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMT 363
             .:..|...|...|.......|.:.:....|:|||.|..||:.|:.|
Human   445 -QHRPVTATSAGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDT 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	8/43 (19%)
		LRR_8	96..155	CDD:290566	24/181 (13%)
		leucine-rich repeat	97..120	CDD:275380	6/25 (24%)
		leucine-rich repeat	121..144	CDD:275380	11/75 (15%)
		LRR_4	144..186	CDD:289563	14/108 (13%)
		leucine-rich repeat	145..168	CDD:275380	8/89 (9%)
		leucine-rich repeat	169..216	CDD:275380	16/46 (35%)
		LRRCT	225..274	CDD:214507	16/58 (28%)
		Ig	295..367	CDD:143165	21/69 (30%)
LINGO3	NP_001094861.1	LRRNT	24..58	CDD:214470	9/35 (26%)
		LRR 1	55..76		7/20 (35%)
		LRR_8	57..138	CDD:290566	20/80 (25%)
		LRR_4	59..95	CDD:289563	8/35 (23%)
		leucine-rich repeat	59..79	CDD:275380	7/19 (37%)
		LRR 2	79..100		1/20 (5%)
		leucine-rich repeat	80..103	CDD:275380	3/22 (14%)
		LRR 3	103..124		4/20 (20%)
		leucine-rich repeat	104..127	CDD:275380	4/22 (18%)
		LRR_RI	111..>286	CDD:238064	21/174 (12%)
		LRR_8	127..>172	CDD:290566	10/44 (23%)
		LRR 4	127..148		10/20 (50%)
		leucine-rich repeat	128..151	CDD:275380	10/22 (45%)
		LRR 5	151..172		0/20 (0%)
		leucine-rich repeat	152..199	CDD:275380	0/46 (0%)
		LRR 6	175..196		0/20 (0%)
		LRR_8	198..258	CDD:290566	4/59 (7%)
		leucine-rich repeat	200..223	CDD:275380	4/22 (18%)
		LRR 7	207..228		0/20 (0%)
		leucine-rich repeat	224..247	CDD:275380	0/22 (0%)
		LRR_8	247..303	CDD:290566	9/55 (16%)
		LRR 8	247..268		0/20 (0%)
		leucine-rich repeat	248..271	CDD:275380	0/22 (0%)
		LRR 9	271..292		5/20 (25%)
		leucine-rich repeat	272..293	CDD:275380	5/20 (25%)
		LRR 10	295..316		5/20 (25%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR 11	319..340		10/20 (50%)
		leucine-rich repeat	322..343	CDD:275380	10/20 (50%)
		I-set	407..497	CDD:254352	24/91 (26%)
		Ig	422..490	CDD:299845	21/71 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910