DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek6 and Lrrc4

DIOPT Version :9

Sequence 1:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001032413.1	Gene:	Lrrc4 / 641521	RGDID:	1560026	Length:	652	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	104/457 - (22%)
Similarity:	171/457 - (37%)	Gaps:	105/457 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LPVCWI-----LLCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLV 75
            |||.::     :||......|.....:|.|.|:|  :|.....:|:...|:.:|..:.:..:.|.
  Rat    18 LPVVYLTAQVWILCAAIAAAASAGPQNCPSVCSC--SNQFSKVVCTRRGLSEVPQGIPSNTRYLN 80

  Fly    76 LNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFM 140
            |.:|:|..:..:.|..|.  :|:.:.|.::.::.|...:|..|..|..::|.||.|.::....|.
  Rat    81 LMENNIQMIQADTFRHLH--HLEVLQLGRNAIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFE 143

  Fly   141 GNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDMHDC-LISYIDP------MSLANLNL------ 192
            ...:||.|:|..||::.:.:|.|..:|.|..||:.:. .:.||..      .:|..|||
  Rat   144 YLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIK 208

  Fly   193 -------------LEF---------------------------------------------LNLK 199
                         ||.                                             |||.
  Rat   209 DMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLA 273

  Fly   200 NNLLESLSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRLSSVSLV---CKGPPAQKDR 261
            :|.|.||...:|..:..|..|.|..|||.|:|.: .:..|::...:.:.|..   |..|...:.|
  Rat   274 HNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDI-LWLAWWLREYIPTNSTCCGRCHAPMHMRGR 337

  Fly   262 TWDSVDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWELNGKILDNDNVLFES 326
            ....||...|.|...   |..:..::::|..:..........|:..|.|     :|.|..||..:
  Rat   338 YLVEVDQASFQCSAP---FIMDAPRDLNISEDRMAELKCRTPPMSSVKW-----LLPNGTVLSHA 394

  Fly   327 E-----SIASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLSEIVQHVLEKTPETFW 386
            .     |:.:|   ..|....|..:|.|.|.|..:|..|:  .|.|.||:  |......|| .|.
  Rat   395 SRHPRISVLND---GTLNFSRVLLIDTGVYTCMVTNVAGN--SNASAYLN--VSSAELNTP-NFS 451

  Fly   387 YF 388
            :|
  Rat   452 FF 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	6/24 (25%)
		LRR_8	96..155	CDD:290566	16/58 (28%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_4	144..186	CDD:289563	14/48 (29%)
		leucine-rich repeat	145..168	CDD:275380	8/22 (36%)
		leucine-rich repeat	169..216	CDD:275380	19/117 (16%)
		LRRCT	225..274	CDD:214507	13/51 (25%)
		Ig	295..367	CDD:143165	18/76 (24%)
Lrrc4	NP_001032413.1	LRRNT	45..78	CDD:214470	8/34 (24%)
		LRR_8	74..132	CDD:404697	13/59 (22%)
		LRR 1	75..96		5/20 (25%)
		leucine-rich repeat	76..99	CDD:275380	6/24 (25%)
		PPP1R42	96..300	CDD:411060	43/205 (21%)
		LRR 2	99..120		4/20 (20%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		LRR 3	123..144		6/20 (30%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		LRR 4	147..168		8/20 (40%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		LRR 5	171..193		5/21 (24%)
		leucine-rich repeat	172..196	CDD:275380	5/23 (22%)
		LRR 6	196..217		4/20 (20%)
		leucine-rich repeat	197..218	CDD:275380	4/20 (20%)
		LRR 7	218..239		2/20 (10%)
		leucine-rich repeat	219..242	CDD:275380	2/22 (9%)
		LRR 8	242..263		0/20 (0%)
		leucine-rich repeat	243..266	CDD:275380	0/22 (0%)
		LRR 9	266..287		8/20 (40%)
		leucine-rich repeat	267..288	CDD:275380	8/20 (40%)
		LRRCT	299..350	CDD:214507	13/51 (25%)
		IG_like	358..440	CDD:214653	22/93 (24%)
		Ig strand B	369..373	CDD:409353	0/3 (0%)
		Ig strand C	380..384	CDD:409353	2/8 (25%)
		Ig strand E	406..410	CDD:409353	1/3 (33%)
		Ig strand F	420..425	CDD:409353	2/4 (50%)
		Ig strand G	433..436	CDD:409353	1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46071
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910